Unprecedented C_(19)-diterpenoid alkaloid glycosides from an aqueous extract of“fu zi”:Neoline 14-O-L-arabinosides with four isomeric L-anabinosyls  

作　　者：Xian-Hua Meng Qing-Lan Guo Cheng-Gen Zhu Jian-Gong Shi 

机构地区：[1]State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medico,Chinese Academy of Medical Sciences and PekingUnion Medical College,Beijing 100050,China

出　　处：《Chinese Chemical Letters》2017年第8期1705-1710,共6页中国化学快报（英文版）

基　　金：Financial support from the National Natural Science Foundation of China(NNSFC,Nos.81630094 and 30825044)

摘　　要：Four structurally unprecedented aconitane-type C_（19）-diterpenoid alkaloid glycosides with isomeric arabinosyls, named aconicarmichosides A–D（1–4）, were isolated from an aqueous extract of ＂fu zi＂, the lateral roots of Aconitum carmichaelii. Their structures were determined as neoline 14-O-a-and 14-O-b-L-arabinopyranosides（1 and 2） and 14-O-a-and 14-O-b-L-arabinofuranosides（3 and 4）, by spectroscopic and chemical methods including 2D NMR experiments and acid hydrolysis. Compounds 1–4 represent the first examples of glycosidic diterpenoid alkaloids.Four structurally unprecedented aconitane-type C_（19）-diterpenoid alkaloid glycosides with isomeric arabinosyls, named aconicarmichosides A–D（1–4）, were isolated from an aqueous extract of ＂fu zi＂, the lateral roots of Aconitum carmichaelii. Their structures were determined as neoline 14-O-a-and 14-O-b-L-arabinopyranosides（1 and 2） and 14-O-a-and 14-O-b-L-arabinofuranosides（3 and 4）, by spectroscopic and chemical methods including 2D NMR experiments and acid hydrolysis. Compounds 1–4 represent the first examples of glycosidic diterpenoid alkaloids.

关 键 词：Aconitum carmichaelii Ranunculaceae Fu zi Aconitane alkaloid glycoside Neoline 14-O-L-arabinoside Aconicarmichosides A–D 

分 类 号：TQ464[化学工程—制药化工]