Synthesis and insecticidal activities of 1,8-naphthyridine derivatives  

作　　者：Qing-Qing Hou Yi-Fei Jing Xu-Sheng Shao 

机构地区：[1]Shanghai Key Laboratory of Chemical Biology,School of Pharmacy,East China University of Science and Technology,Shanghai 200237,China

出　　处：《Chinese Chemical Letters》2017年第8期1723-1726,共4页中国化学快报（英文版）

基　　金：financial supported by National Natural Science Foundation of China(Nos.21372079,21472046);Shanghai Pujiang Program(No.14PJD012)

摘　　要：1,8-Naphthyridines（NAP） are biological important scaffolds in bioactive molecules design. By hybrid of NAP with neonicotinoid core structure, nine novel NAP derivatives were synthesized and subjected to insecticidal activities evaluation. Some of the compounds showed excellent insecticidal activity against cowpea aphids（Aphis craccivora） with LC_（50） values ranging from 0.011 mmol/L to 0.067 mmol/L. The results indicated that 1,8-naphthyridine can be used as insecticidal structure for further modification.1,8-Naphthyridines（NAP） are biological important scaffolds in bioactive molecules design. By hybrid of NAP with neonicotinoid core structure, nine novel NAP derivatives were synthesized and subjected to insecticidal activities evaluation. Some of the compounds showed excellent insecticidal activity against cowpea aphids（Aphis craccivora） with LC_（50） values ranging from 0.011 mmol/L to 0.067 mmol/L. The results indicated that 1,8-naphthyridine can be used as insecticidal structure for further modification.

关 键 词：1.8-Naphthyridine Insecticide ativity Neonicotinoid Aphid 

分 类 号：TQ453[化学工程—农药化工]