Design,synthesis and insecticidal activities of novel anthranilic diamides containing polyfluoroalkyl pyrazole moiety  

作　　者：Jian-Jun Shi Gui-Hua Ren Ning-Jie Wu Jian-Quan Weng Tian-Ming Xu Xing-Hai Liu Cheng-Xia Tan 

机构地区：[1]College of Chemical Engineering,Zhejiang University of Technology,Hangzhou 310014,China [2]School of Chemistry and Chemical Engineering,Huangshan University,Huangshan 245041,China [3]Zhejiang Base of National Southern Pesticide Research Centre,Zhejiang Research Institute of Chemical Industry,Hangzhou 310023,China

出　　处：《Chinese Chemical Letters》2017年第8期1727-1730,共4页中国化学快报（英文版）

基　　金：supported by Key Projects of the National Science and Technology Pillar Program of China(No.2011BAE06B01-20)

摘　　要：In order to discover new molecules with good insecticidal activities, a series of anthranilic diamides containing polyfluoroalkyl pyrazole were designed and synthesized, and their structures were characterized by1 H NMR and HRMS. Bioassays demonstrated that some of the title compound exhibited excellent insecticidal activities. The larvicidal activities of compound 8a, 8c, 8g, 8k and 8l against Mythimna separata Walker were 100% at 0.8 mg/L. The insecticidal activities of compound 8a, 8c,8e, 8g, 8k and 8l against Plutella xylostella Linnaeus were 100% at 0.4 mg/L. Surprisingly compounds 8a and 8c still showed 100% larvicidal activities against Plutella xylostella Linnaeus at 0.08 mg/L comparable to the commercialized Chlorantraniliprole. The LC_（50） of compound 8a and 8c against M. separata is 0.048 and 0.043 mg/L respectively.In order to discover new molecules with good insecticidal activities, a series of anthranilic diamides containing polyfluoroalkyl pyrazole were designed and synthesized, and their structures were characterized by1 H NMR and HRMS. Bioassays demonstrated that some of the title compound exhibited excellent insecticidal activities. The larvicidal activities of compound 8a, 8c, 8g, 8k and 8l against Mythimna separata Walker were 100% at 0.8 mg/L. The insecticidal activities of compound 8a, 8c,8e, 8g, 8k and 8l against Plutella xylostella Linnaeus were 100% at 0.4 mg/L. Surprisingly compounds 8a and 8c still showed 100% larvicidal activities against Plutella xylostella Linnaeus at 0.08 mg/L comparable to the commercialized Chlorantraniliprole. The LC_（50） of compound 8a and 8c against M. separata is 0.048 and 0.043 mg/L respectively.

关 键 词：Polyfluoroalkyl pyrazole carboxamide Insecticidal activity Chlorantraniliprole Ryanodine receptors 

分 类 号：TQ453[化学工程—农药化工]