Benign perfluoroalkylation of uracils and uracil nucleosides via visible light-induced photoredox catalysis  

作　　者：Ben-Hou Zhang Jing-Jing Kong Yang Huang Yue-Guang Lou Xiao-Fei Li Chun-Yang He 

机构地区：[1]School of Pharmacy,Zunyi Medical University,Zunyi 563003,China [2]Dafeng Marine Industrial Institute of Nanjing Tech University,Yancheng 224145,China

出　　处：《Chinese Chemical Letters》2017年第8期1751-1754,共4页中国化学快报（英文版）

基　　金：financially supported by the Young Talents Cultivation Program of the China Association for Science and Technology(No.2015-41);The Training Programme Foundation for the Talents of the Zun Yi Science and Technology Bureau(No.201540);Key Programs of Guizhou Province(125 Program,No.2015039);The Natural Science Foundation of Jiangsu Province(No.BK20141265)

摘　　要：In this work, an efficient and facile method for the preparation of 5-perfluoroalkylation uracils and uracil nucleosides through visible-light-mediated reaction has been developed. The reaction processes in high efficiency under mild reaction conditions and show broad substrate scope by employing commercial available perfluoroalkyl sources, thus demonstrates high potent application in life and medicinal science.In this work, an efficient and facile method for the preparation of 5-perfluoroalkylation uracils and uracil nucleosides through visible-light-mediated reaction has been developed. The reaction processes in high efficiency under mild reaction conditions and show broad substrate scope by employing commercial available perfluoroalkyl sources, thus demonstrates high potent application in life and medicinal science.

关 键 词：Uracils Uracil Nucleosides Blue LED Photoredox catalysis Perfluoroalkylation 

分 类 号：TQ460.1[化学工程—制药化工]