血浆suPAR水平与冠状动脉慢血流的相关性分析  

Association of the plasma soluble urokinase-type plasminogen activator receptor level and the coronary slow flow phenomenon

作　　者：郑桂安[1] 陈建东[1] 董帝辉 

机构地区：[1]福建医科大学附属漳州市医院心内科,福建省漳州市363001

出　　处：《中国心血管病研究》2017年第8期710-714,共5页Chinese Journal of Cardiovascular Research

基　　金：福建省自然科学基金项目（项目编号：2016J01486）;福建省卫计委青年科研课题（项目编号：2014-1-80）

摘　　要：目的 观察血浆可溶性尿激酶型纤溶酶原激活物受体（suPAR）水平、高敏C反应蛋白（hs-CRP）与冠状动脉慢血流的关系,探讨suPAR在冠脉慢血流中的作用及影响冠脉慢血流的相关因素.方法 选取疑诊为冠心病但冠脉造影正常的患者,据冠脉TIMI帧数将患者分为慢血流组（53例）和正常对照组（42例）,记录其冠心病危险因素,检测血浆suPAR、hs-CRP等水平.结果 两组间糖尿病、高血压、高脂血症、早发冠心病家族史等比率及血脂水平均未见统计学差异,慢血流组吸烟率较对照组明显升高（72％比48％,P=0.02）.同对照组相比,慢血流组血浆suPAR水平[（3.01±0.05）ng/ml比（1.33±0.06）ng/ml,P＜0.01]和hs-CRP水平[（1.07±0.04）mg/L比（0.71±0.05）mg/L,P＜0.01]均明显升高,差异具有统计学意义.一元回归分析显示,血浆suPAR、hs-CRP水平与冠脉TIMI帧数均呈明显正相关（R2=0.83,P＜0.01;R2=0.71,P＜0.01）.多元回归分析显示,suPAR、hs-CRP、吸烟均与冠脉TIMI帧数呈正相关（R2=0.64,P＜0.01）,其中suPAR的影响力最大（标准化β=0.62）.结论 血浆suPAR、hs-CRP水平和吸烟与冠脉慢血流呈明显正相关,而且血浆suPAR水平对冠脉慢血流的预测价值较高.Objective To investigate the relationships between plasma soluble urokinase-type plasminogen activator receptor（suPAR）,high-sensitive reactive protein（hs-CRP） and coronary slow flow（CSF）,and to explore the effect of suPAR on CSF and the factors influencing CSF.Methods Patients with suspicion of coronary artery disease who had angiographically normal coronary arteries were enrolled.Based on coronary TIMI frame count,patients were divided into CSF group（n=53） and normal coronary flow（NCF） group（n=42）.Coronary risk factors were documented.Plasma suPAR and hs-CRP levels were measured.Results There were no difference in the incidences of diabetes,hypertension,hyperlipidemia and early familial coronary artery disease between the two groups,as well as in the lipid levels.The rate of smoking was significantly higher in the CSF group than the NCF group （72％ vs 48％,P=0.02）.Plasma suPAR and hs-CRP levels in the CSF group were significantly increased compared with the NCF group[（3.01±0.05）ng/ml vs （1.33±0.06）ng/ml,P＜0.01;（1.07±0.04）mg/L vs （0.71-± 0.05）mg/L,P＜0.01].Plasma suPAR and hs-CRP levels correlated significantly with coronary TIMI frame count as revealed by linear regression analysis （R2=0.83,P＜0.01;R2=0.71,P＜0.01）.The multiple regression analysis showed that suPAR,hs-CRP and smoking were positively related with coronary TIMI frame （R2=0.64,P＜0.01）,particularly,suPAR had the greatest impact （standard β3=0.62）.Conclusion The present study demonstrates that the plasma suPAR,hs-CRP levels and smoking are positively related with CSF.In particular,the plasma suPAR level is the best predictor to the CSF phenomenon.

关 键 词：可溶性尿激酶型纤溶酶原激活物受体 慢血流 TIMI帧数 冠状动脉 

分 类 号：R541.4[医药卫生—心血管疾病]