流感疫苗黏膜佐剂研究进展  

Research progress in mucosal adjuvants for influenza vaccines

作　　者：李树香 徐静 

机构地区：[1]国药中生生物技术研究院有限公司第三研究室,北京101111

出　　处：《国际生物制品学杂志》2017年第4期175-179,共5页International Journal of Biologicals

摘　　要：当前流感疫苗主要为肌内注射灭活疫苗和滴鼻减毒活疫苗。对于预防呼吸道传播的流感，抗原特异性黏膜免疫应答非常重要。现有资料显示，两种疫苗都存在不可避免的局限性，为解决这个问题，需要对黏膜佐剂流感疫苗进行深入的研究。此文对进入临床试验的流感疫苗黏膜佐剂进行综述。Current influenza vaccines mainly include intramuscular inactivated vaccines and intranasal attenuated live vaccines. Antigen-specific mucosal immune response is important for preventing influenza spread via respiratory transmission. Available data show that both vaccines have inevitable limitations. In order to solve this problem, in-depth studies on mucosal adjuvant influenza vaccines are needed. In this paper, the mucosal adjuvants used in influenza vaccines entered clinical trial are reviewed.

关 键 词：流感疫苗 佐剂 免疫 免疫 黏膜 

分 类 号：R392[医药卫生—免疫学]