中年高血压患者胰岛素抵抗与认知功能障碍的关系  

Relationship of insulin resistance with cognitive dysfunction in middle-aged patients with hypertension

作　　者：邓超蓝[1] 梁丽珠[1] 陈晓键[1] 

机构地区：[1]广东省江门市第二人民医院心内科,江门市529020

出　　处：《广西医学》2017年第8期1192-1194,共3页Guangxi Medical Journal

摘　　要：目的探讨中年高血压患者胰岛素抵抗与认知功能障碍的关系。方法选择中年高血压患者96例,根据简短精神状态检查评分结果将患者分为认知功能障碍组40例和认知功能正常组56例,测定所有患者的血压,并检测其血脂、FBG及空腹胰岛素水平,计算胰岛素抵抗指数(IRI),分析中年高血压患者认知功能障碍的危险因素。结果两组间文化程度、胰岛素抵抗指数、DBP比较,差异有统计学意义(P<0.05)。Logistic多因素分析结果显示,文化程度及IRI是中年高血压患者发生认知功能障碍的危险因素(P<0.05)。结论胰岛素抵抗是中年高血压患者认知功能障碍的独立危险因素之一,临床中需对此加以重视。Objective To explore the relationship of insulin resistance with cognitive impairment in middle-aged patients with hypertension. Methods Ninety-six middle-aged patients with hypertension were divided into cognitive dysfunction group（n =40） and normal cognitive function group（n = 56） according to the score of Mini-Mental State Examination. Blood pressure was measured,and the levels of blood lipid,FBG and fasting insulin were detected in all patients. Insulin resistance index（IRI） was calculated. The risk factors for cognitive dysfunction in middle-aged patients with hypertension were analyzed. Results There were significant differences in the education background, IRI and DBP between the two groups （ P 〈 0.05 ）. The result of logistic multivariate analysis showed that education background and IRI were the risk factors for cognitive dysfunction in middle-aged patients with hypertension （ P 〈 0.05 ）. Conclusion Insulin resistance is one of the risk factors for cognitive dysfunction in middle-aged patients with hypertension,which merits special attention in clinical.

关 键 词：高血压 胰岛素抵抗 认知障碍 中年人 

分 类 号：R544.1[医药卫生—心血管疾病]