阿司匹林与结直肠肿瘤  

Aspirin and colorectal neoplasms

作　　者：黄震华[1] 

机构地区：[1]上海交通大学医学院附属第九人民医院心血管病研究室,上海200011

出　　处：《中国新药与临床杂志》2017年第8期446-450,共5页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：阿司匹林是一个经典的抗血小板药物,在预防冠状动脉血栓栓塞中发挥重要作用。近年来,大量研究观察到阿司匹林有一定的预防结直肠肿瘤的作用,可减少结直肠肿瘤远处转移的风险并降低死亡率。其作用机制是阿司匹林可减少花生四烯酸代谢产物前列腺素E2(PGE2)的产生,而PGE2与促进肿瘤的发生、发展和转移有关。Aspirin is a classical anti-platelet drug, and plays an important role in preventing coronary artery thrombo- embolism. Recently, a large amount of studies showed that aspirin had certain function of preventing colorectal cancer, reduced the risk of distant metastasis and mortality rate of colorectal cancer. The mechanism of action is that aspirin can decrease the production of prostaglandin E2 （PGE2） , which is the metabolic product of arachidonic acid and is related to promoting the development, progression and metastasis of neoplasms.

关 键 词：阿司匹林 结直肠肿瘤 冠状动脉疾病 

分 类 号：R972.7[医药卫生—药品] R375.3[医药卫生—药学]