产生类抗体的自身免疫性溶血性贫血患者的输血选择  

Blood Transfusion Selection in Patients with Autoimmune Hemolytic Anemia Producing Class Antibodies

作　　者：丁琴丽[1] 陈宝龙[1] 邱芳[1] 

机构地区：[1]赣南医学院第一附属医院输血科,江西赣州341000

出　　处：《中国实验血液学杂志》2017年第4期1208-1211,共4页Journal of Experimental Hematology

摘　　要：目的:对淋巴瘤并发自身免疫性溶血性贫血(AIHA)患者交叉配血不合的原因进行分析,为患者多次输血提供相容性血液,以改善其当前贫血状况。方法:采用试管法对患者进行常规ABO血型鉴定、Rh分型及直接抗人球蛋白试验;采用盐水法、微柱凝胶卡对患者进行抗体鉴定;采用盐水法、凝聚胺法和抗人球蛋白法对患者进行交叉配血试验。结果:该患者血清中检出了自身抗体,在放散液中检出类抗-Ce抗体;输注相应抗原阴性的血液后,患者血红蛋白水平得到显著提升。结论:只有首先准确鉴定出患者血清及放散液中存在的抗体,筛选出相应抗原阴性的血液,才能够保证输血的安全性、有效性。Objective： To analyze the reasons for the incompatibility of cross matching in lymphoma patients complicated by autoimmune hemolytic anemia（ AIHA）,and to provide compatible blood to patients for multiple blood transfusion. Methods： The test tube method was used for routine identification of ABO blood group,Rh typing and direct anti-globulin test; the patients antibody was identified by saline water method,micro column gel card; and the saline water method,Polybrene method and antiglobulin method were used for blood cross matching test of the patients.Results： In the serum of the patient,positive autoantibodies were detected,in the elution,the Ce antibody was detected.After infusion of the corresponding antigen-negative blood,the patient＇s hemoglobin level was significantly improved.Conclusion： Only firstly accurately identifying antibodies existed in serum and elution,then selecting corresponding antigen negative blood,can ensure the safety and effectiveness of blood transfusion.

关 键 词：自身免疫性溶血性贫血 类抗体 血型鉴定 抗体鉴定 交叉配血试验 

分 类 号：R556.6[医药卫生—血液循环系统疾病] R733.1[医药卫生—内科学]