巨噬细胞在红系造血中的作用  

Role of Macrophages in Erythropoiesis

作　　者：宋丹丹[1] 吴凌云[1] 

机构地区：[1]上海交通大学附属第六人民医院血液科,上海200233

出　　处：《中国实验血液学杂志》2017年第4期1223-1226,共4页Journal of Experimental Hematology

摘　　要：红系生成及其调节被认为发生于骨髓内的特定结构造血岛。巨噬细胞对红系生成的促进作用及与红系生成龛——造血岛的结构及功能完整性息息相关,而造血岛的完整性通过细胞间的黏附分子得以实现。在成年人红系生成的动态平衡中,巨噬细胞主要发挥两方面的作用:一是保留未成熟红细胞于骨髓,促进有核红细胞分化成熟为网织红细胞,二是清除衰老的红细胞。近年来的研究发现,在生理或病理条件下,机体均可通过对巨噬细胞功能状态的调控来影响红系造血。本文综述了该方面近年来取得的新进展,讨论的问题包括巨噬细胞与红细胞之间的黏附及调控因子,巨噬细胞在红细胞发育分化中的作用和不同状态下巨噬细胞对红系造血的影响等。Terminal erythroid differentiation and its regulation occurs in the bone marrow specialized structure termed erythroblastic islands. The role of macrophages in erythropoiesis is closely related with the integrity of erythroblastic island,which is reliant on adhesive interactions between erythroid and macrophage cells. In regulating red blood cell homeostasis of adult,macrophages have 2 major roles,retaining erythroblast in bone marrow,controlling the final maturation of erythroblasts into reticulocytes and clearing old erythrocytes. Recent research demonstrated that body can affect erythropoiesis by regulating the function of macrophages in physiological or pathological conditions. This paper review focuses on the new advances of this aspect in recent years,including adhesion factor and regulatory factor between macrophage and red blood cells,role of macrophage in development of red blood cells,effect of macrophage on erythropoiesis in different conditiones and so on.

关 键 词：巨噬细胞 红细胞 红系造血 造血岛 

分 类 号：R331.2[医药卫生—人体生理学] R322.2[医药卫生—基础医学]