外泌小体在白血病细胞和骨髓间充质干细胞交叉对话中的作用  

Role of Exosomes in the Cross-Talk between Leukemia Cells and Mesenchymal Stem Cells

作　　者：杨雅芝[1,2] 张小燕[1,2] 房丽君[1,2] 万倩[1,2] 李剑[1] 

机构地区：[1]南昌大学第二附属医院血液重点实验室,江西南昌330006 [2]南昌大学研究生院医学部,江西南昌330006

出　　处：《中国实验血液学杂志》2017年第4期1255-1258,共4页Journal of Experimental Hematology

摘　　要：越来越多的证据提示,骨髓微环境在白血病的发生、发展和耐药等过程中发挥着重要的作用,其不仅是造血干细胞增殖、分化和成熟的土壤,也是白血病微小残留病灶潜在的天然庇护所以及复发和产生多药耐药的根源。间充质干细胞(mesenchymal stem cells,MSC)是骨髓微环境中重要的基质细胞,在近年来被证明是影响白血病细胞生物学特性的主要因素之一。MSC和白血病细胞不仅可以通过直接接触相互影响,还可以通过分泌外泌小体(exosome)进行交叉对话。外泌小体由多种活细胞分泌的纳米级囊泡小体,其中含有蛋白质、RNA和mRNA等多种组分,参与细胞间的物质交换和信息交流,在多种生理和病理过程中发挥着重要作用。外泌体的研究是白血病与微环境的一个新兴领域,将极大地推动有关白血病的研究进展,为白血病治疗带来新的契机。More and more studies have demonstrated that bone marrow microenvironment,the fundament of the multiplication and differentiation of hematopoietic stem cells,plays a crucial role in leukemia progression and resistance to treatment. It provides a permissive environment for minimal residual disease and contributes to relapse and multidrug resistance. Mesenchymal stem cells are a kind of important stromal cells in bone marrow niche. In recent researches,MSC have been shown to be one of the major factors modulating the biological features of leukemia cells. The cross-talk betw een MSC and leukemia cells can take place not only by direct contact,but also by exosome exchange. Exosomes are nano-sized vesicles released by a variety of cells,w hich contain protein,RNA and mRNA. They are effective tools for transportation betw een cells,and play an important role in many physiological and pathological processes. Exosome is a new topic in the research of leukemia and microenvironment. The exosome research w ill help elucidate the mechanism of leukemia,thus providing new ideas for the treatment.

关 键 词：白血病 骨髓间充质干细胞 外泌小体 白介素 

分 类 号：R733.7[医药卫生—肿瘤]