针刺十三鬼穴对肝性脑病患者肝功能、血氨及β-内啡肽水平的影响  

Effect of Acupuncture at Thirteen Evil Acupoints on Liver Function,and the Contents of Blood Ammonia and β-endorphin in Patients with Hepatic Encephalopathy

作　　者：苏红慧[1] 崔厚松 苏会玲[3] 

机构地区：[1]华北石油管理局总医院药材科,河北沧州062552 [2]河北省衡水市故城县医院中医内科,河北衡水253800 [3]华北石油管理局总医院肿瘤科,河北沧州062552

出　　处：《针刺研究》2017年第4期342-345,共4页Acupuncture Research

摘　　要：目的:观察针刺十三鬼穴对肝性脑病的疗效,并探讨其作用机制。方法:肝性脑病患者随机分为针刺组38例和西药组36例。西药组予门冬氨酸鸟氨酸、支链氨基酸静脉滴注治疗,针刺组在西药组治疗基础上加用针刺十三鬼穴,均治疗1周。评价两组患者临床疗效,采用全自动生化分析仪检测患者血肝功能、血氨,采用酶联免疫夹心吸附法测定患者血β-内啡肽的变化。结果:治疗1周后,西药组总有效率为69.4%(25/36),针刺组为89.5%(34/38),针刺组优于西药组(P<0.05)。血清天门冬氨酸氨基转移酶、丙氨酸氨基转移酶、总胆红素,血浆血氨及β-内啡肽水平均较治疗前明显降低(P<0.01),且针刺组降低幅度大于西药组(P<0.05,P<0.01)。结论:在西药治疗的基础上针刺十三鬼穴,可增强对肝性脑病的治疗效果,改善肝性脑病患者肝功能,降低血氨、β-内啡肽的水平。Objective To observe the therapeutic effect of acupuncture at thirteen evil acupoints in patients with hepatic encephalopathy,and to explore its possible mechanism.Methods Patients with hepatic encephalopathy were randomly divided into acupuncture group（n=38）and western medicine group（n=36）.Patients in the western medicine group were treated by intravenous injection of aspartate ornithine and branched chain amino acids,and those in the acupuncture group were treated with acupuncture at thirteen evil acupoints on the basis of the western medicine.All the patients were treated for 1 week.The liver function and blood ammonia were measured by automatic biochemical analyzer.The changes of plasma β-endorphin were measured by enzyme-linked immunosorbent assay（ELISA）.Results Following the treatment,of the 36 and 38h epatic encephalopathy patients in the western medicine and acupuncture groups,12 and 18 experienced a marked improvement in their symptoms,13 and 16 were effective,and 11 and 4 invalid,with the effective rates being 69.4% and 89.5%,respectively.Compared with pre-treatment,the levels of serum aspartate aminotransferase,alanine aminotransferase,total bilirubin,and plasma β-endorphin and blood ammonia were significantly lower in both western medicine and acupuncture groups（P〈0.01）,and the therapeutic effects of the acupuncture group were obviously superior to those of the western medicine group in the above mentioned indexes（P〈0.05,P〈0.01）.Conclusion Treatment of acupuncture at thirteen evil acupoints combined with western medicine can enhance the curative effect of hepatic encephalopathy,improve patients＇ liver function and decrease the levels of plasma ammonia andβ-endorphin.

关 键 词：针刺 十三鬼穴 肝性脑病 血氨 β-内啡肽 

分 类 号：R246.6[医药卫生—针灸推拿学]