复杂网络挖掘分析9家医院冠心病室性心律失常患者的用药规律  

Analysis of Medication Rules in Coronary Artery Disease Patients with Ventricular Arrhythmia Based on Complex Networks

作　　者：张萍[1] 苏博[1] 高铸烨[2] 徐浩[3] 徐凤芹[1] 

机构地区：[1]中国中医科学院西苑医院综合内科,北京100091 [2]中国中医科学院西苑医院教育处,北京100091 [3]中国中医科学院西苑医院心血管中心,北京100091

出　　处：《中国中西医结合杂志》2017年第8期930-933,共4页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：北京市科委课题"冠心病中西医结合诊治规律的数据挖掘及验证研究"(No.D08050703020801)

摘　　要：目的利用复杂网络技术分析中医药治疗冠心病室性心律失常的证候、治法和药物之间的关系,挖掘其用药规律。方法采用病证结合的方法,基于冠心病个体化诊疗信息平台,调取386例冠心病室性心律失常住院患者的临床信息,利用SQL Server 2000工具对人口学资料、一般临床特点、证候、治法及方药数据进行转换、加载,利用Business Objects软件进行冠心病室性心律失常临床需求的多维主题查询、分析及Web多维分析;利用Oracle Database 10g实现冠心病室性心律失常证候分布、遣方用药规律的挖掘分析。以证候、治法、中药及其功效作用网络节点建立复杂网络图,通过计算机分析与处理,将反复出现的证候-中药、药物-功效等关系连接成网络结构,即复杂网络分析。结果通过复杂网络方法挖掘发现,冠心病室性心律失常的证候主要以气虚、血瘀、痰浊为主;药物-证候复杂网络图分析发现:血瘀证,多用丹参、当归、赤芍、川芎、红花、桃仁等活血药;气虚证,多用茯苓、甘草等补气健脾药;痰浊证,多用半夏、陈皮等祛痰化浊药。结论通过复杂网络分析,挖掘出冠心病室性心律失常主要以补气、活血、化痰为主要治法,为临床用药提供一定指导。Objective Using complex networks,to analyze the relationships among syndrome,therapeutic methods,and Chinese herbs in coronary artery disease（ CAD） patients with ventricular arrhythmias（ VA）,and to dig out its medication rules. Methods Using combination method of disease identification and syndrome typing,clinical information of 386 CAD inpatients with VA were collected on the basis of CAD individualized information platform. Using SQL Server 2000 tool,demographic data,general clinical characteristics,syndromes,treatment methods,and prescription data were transferred and loaded.Using Business Objects Software,clinical needs of CAD patients with VA were searched and analyzed multidimensionally,and Web analyzed. Using Oracle Database 10 g,the syndrome distribution of CAD patients with VA and the rules of drug use were analyzed. Using the syndrome,treatment methods,Chinese herbs and their functions as network nodes,the complex network were established. By computer analysis and processing,recurrent syndromes-Chinese herbs,drugs-efficacy relationships were connected to build network structure. This was so-called complex network analysis. Results By complex network digging,qi deficiency syndrome,blood stasis syndrome,phlegm turbidity syndrome were main syndromes for CAD patients with VA. By complex network analysis,Salvia Miltiorrhiza,Angelica sinensis,Ligusticum Chuanxiong Hort,Carthamus tinctorius Linn.,peach seed,etc. blood activating Chinese drugs were mostly used for blood stasis syndrome. Poria cocos,Glycyrrhiza uralensis Fisch,etc. qi supplementing Pi invigorating Chinese drugs were mostly used for qi deficiency syndrome. Pinellia ternata,tangerine peel,etc. phlegm resolving turbidity eliminating Chinese drugs were mostly used for phlegm turbidity syndrome. Conclusions Through analysis of complex network,main methods for CHD patients with VA were invigorating qi,promoting blood circulation,and resolving phlegm. It would provide some guidance for clinical medication.

关 键 词：冠心病 室性心律失常 证候 药物与方剂 复杂网络 

分 类 号：R259[医药卫生—中西医结合]