硫代二乙酸二甲酯的合成研究  

Synthesis of Dimethyl 2,2'-Thiobisacete

作　　者：葛雅莉[1] 麦坚华 盘茂森[1] 

机构地区：[1]广东石油化工学院化学工程学院,广东茂名525000

出　　处：《精细化工中间体》2017年第3期57-59,共3页Fine Chemical Intermediates

基　　金：广东省橡塑材料制备与加工工程技术研究中心(2015B090903083);茂名市科技计划项目(20150310);广东石油化工学院人才引进项目(2015YC01)

摘　　要：以氯乙酸为原料,经甲酯化、巯基化、碘氧化偶联,3步反应合成硫代二乙酸二甲酯。并对碘化偶联反应中催化剂的用量、反应温度、反应时间对收率的影响进行了探讨。本工艺原料廉价易得,操作简单。In this paper, dimethyl 2,2＇-thiobisacetate was synthesized in 3 steps using chloroacetic acid as the starting material. In the first step, methyl chloroacetate was prepared by esterification. In the second step, methyl thioglycolate was prepared by thiolation,. In the third step, the target product was synthesized by iodine oxidation. Several factors effeeting the iodine oxidation coupling reaction including the amount of catalyst, reaction temperature and reaction time were studied. This synthetic route had the advantage of cheap materials and simple operation.

关 键 词：氯乙酸 氯乙酸甲酯 巯基乙酸甲酯 硫代二乙酸二甲酯 

分 类 号：O623.82[理学—有机化学]