不伴有变应性鼻炎小儿鼾症序列治疗  

Sequent therapy for children snoring without allergic rhinitis

作　　者：周涛[1] 刘业海[1] 王大明[1] 张磊[1] 陈斌[1] 里晓红[1] 马燕[1] 杨清[1] 姚长玉[1] 

机构地区：[1]安徽医科大学第一附属医院耳鼻咽喉头颈外科,合肥230022

出　　处：《中国中西医结合耳鼻咽喉科杂志》2017年第4期281-284,268,共5页Chinese Journal of Otorhinolaryngology in Integrative Medicine

基　　金：2014年高等教育振兴计划人才项目基金

摘　　要：目的探讨不伴有严重变应性鼻炎小儿鼾症的有效治疗方法。方法病例为2014年5月~2016年6月我院门诊收治的70例不伴有变应性鼻炎小儿鼾症,依据随机对照原则分为观察组(35例)与对照组(35例),所有病例使用抗生素治疗1周,同时使用左西替利嗪治疗1周;观察组晨起空腹加用强的松5mg,连续用药1周后停药,饭后再加用一片儿童维生素D钙咀嚼片,对照组同期给予安慰剂。一周后二组同时联合使用左西替利嗪、孟鲁司特钠以及维生素D钙咀嚼片治疗3周;治疗前、治疗1周后、治疗4周后患者的症状评分根据Carlos O’Connor-Reina的家长调查问卷获得。结果与治疗前相比,实验组及对照组症状评分均呈明显下降趋势,差异均有统计学意义(P<0.05)。治疗后第1周,观察组各项症状评分均低于对照组,差异均有统计学意义(P<0.05);实验组总有效率48.57%,对照组总有效率25.71%,二组有效率差异有统计学意义(P<0.05)。治疗后第4周,实验组各项症状评分均低于对照组,差异均有统计学意义(P<0.05);实验组总有效率68.57%,对照组总有效率42.86%,二组有效率差异有统计学意义(P<0.05)。结论强的松联合维生素D钙咀嚼片在不伴有变应性鼻炎小儿鼾症治疗中有明显的辅助治疗作用。Objective To study an effectivity therapeutic method for children snoring disease without allergic rhinitis. Methods follow up 70 cases of children with sleep apnea without allergic rhinitis in outpatient from May 2014 to June 2016.According to the randomized controlled principle divided the children into study group and control group, All patients take antibiotics for 1 week, combined with monteluk and levocetirizine dihydrochloride for 1 weeks.And the study group were added with prednisone in the morning for 1 week. And added with vitamin D calcium chewable tablets after dinner for 1 weeks.As the same time, control group were treated using placebo.Then all patients take the levocetirizine dihydrochloride,？monteluk and vitamin D calcium chewable tablets for 3 weeks. The symptom score of before and lweck,4 weeks after the treatment was obtained according to the parents questionnaire of Carlos o ＂Connor-Reina. Results The symptom score of study group and control group were appeared a downward trend,compared with before treatment,and the difference was statistically significant （P〈0.05）. Study group was better than control points after treatment for 1 week,and the difference was statistically significant （P〈0.05）. The effective rate of study group was 48.57%,and the control group was 25.71%,and the difference was statistically significant （P〈0.05）. Study group was better than control points after treatment for 1 week,and the difference was statistically significant （P〈0.05）. The effective rate of study group was 68.57%, and the control group was 42.86%,and the difference was statistically significant （P〈0.05）. Conclusion When used prednisone in combination with vitamin D calcium chewable tablets is recognised as the more effective treatment for children＇s snoring without allergic rhinitis.

关 键 词：小儿鼾症 糖皮质激素 维生素D 药物治疗 

分 类 号：R766[医药卫生—耳鼻咽喉科]