声辐射力脉冲弹性成像结合HMGB1在宫颈癌分期中的初步应用  

The Application of Acoustic Radiation Force Impulse Imaging combined with HMGB1in Staging of Cervical Cancer

作　　者：张桂俊[1] 杨宗利[1] 刘荣桂[1] 臧翊辰 丁兆艳[1] 李云萍[1] 王正滨[1] Zhang Guijun Yang Zongli Liu Ronggui et al(Department of Ultrasound, the Affiliated Hospital of QingDao University, Qingdao, Shandong 266003, Chin)

机构地区：[1]青岛大学附属医院超声科,青岛市266555

出　　处：《中国超声医学杂志》2017年第8期724-727,共4页Chinese Journal of Ultrasound in Medicine

摘　　要：目的探讨声脉冲辐射力弹性成像(ARFI)技术结合高迁移率族蛋白1(HMGB1)在宫颈癌分期中的应用价值。方法应用ARFI技术测量42例宫颈癌患者(宫颈癌组)、55例宫颈上皮内瘤样病变(CIN组)及40例健康体检者(对照组)宫颈声触诊组织量化值(VTQ)。三组均采用酶联免疫分析法(ELISA)检测血清HMGB1浓度,采用电化学发光免疫法检测血清CA125、CEA水平。分析宫颈癌组VTQ值、血清HMGB1水平与CA125、CEA之间的相关性。结果宫颈癌组VTQ值(2.43±0.87)m/s大于CIN组(1.61±0.73)m/s和对照组(1.55±0.45)m/s;差异有显著统计学意义(P<0.01)。宫颈癌组HMGB1(9.42±3.51)ng/ml大于CIN组(3.25±2.89)ng/ml和对照组(3.13±1.53)ng/ml,差异有统计学意义(P<0.01)。宫颈癌组I、Ⅱ、Ⅲ+Ⅳ期VTQ值、血清HMGB1水平随分期增加而增大,差异有统计学意义(P<0.05);CIN组与对照组比较,VTQ值及血清HMGB1水平差异无统计学意义(P>0.05)。宫颈癌组VTQ、血清HMGB1水平与CA125、CEA呈正相关(P<0.01)。结论声辐射力脉冲弹性成像技术结合血清HMGB1水平有助于宫颈癌范围及分期的评估。Objective To explore the application value of acoustic radiation force impulse imaging（ARFI）combined with high mobility group box-l（HMGB1）in staging of cervical cancer.Methods A total of 137 participants were included in this study,categorized as 40 patients with normal cervix（normal cervix group）,55 patients with cervical intraepithelial nepolasia（CIN group）and 42 patients with cervical cancer（cervical cancer group）.The virtual touch tissue quantification（Vs）was measured and recorded.Serum 1evels of the HMGB1 protein were examined using commercially available ELISA kits.Cancer antigen 125（CA125）and carcinoembryonic antigen（CEA）levels among the cases in the three groups were measured by electrochemiluminescence immunoassay method.The correlation between them was analyzed in the cervical cancer group.Results The Vs of the cervical cancer group（2.43±0.87）m/s was significantly higher than the normal cervix group（1.55±0.45）m/s and the CIN group（1.61±0.73）m/s（P〈0.01）.Serum HMGB1 levels were significantly elevated in the cervical cancer group（9.42±3.51）ng/ml compared with normal cervix group（3.13±1.53）ng/ml and CIN group（3.25±2.89）ng/ml（P〈0.01）.The Vs and serum HMGB1 levels increased with the stage of cervical cancer（P〈0.05）,while there was no significantly difference between the CIN group and normal cervix group（P〈0.05）.Moreover,VTQ and HMGB1 were positively correlated with CA125 and CEA levels in the cervical cancer group（P〈0.01）.Conclusions ARFI combined with HMGB1 could be helpful in staging of cervical cancer.

关 键 词：宫颈癌 超声检查 声脉冲辐射力成像 高迁移率族蛋白1 

分 类 号：R445.1[医药卫生—影像医学与核医学] R737.33[医药卫生—诊断学]