双酚A对记忆功能的影响及其机制研究进展  

Effects of Bisphenol A on Animal Memory Function and Its Mechanism

作　　者：廖云燕[1] 高志英[1] 刘忠瑞[1] 李洋洋[1] 王立波[1] 

机构地区：[1]哈尔滨医科大学药学院药物化学与天然药物化学教研室,黑龙江哈尔滨150081

出　　处：《现代预防医学》2017年第16期3061-3064,共4页Modern Preventive Medicine

基　　金：黑龙江省大学生创新项目基金[项目编号201610226069];哈尔滨市应用技术研究与开发项目基金[项目编号2016RAQXJ184]

摘　　要：双酚A通过塑料食品包装材料迁移到食品中,从而被人体吸收,其可诱发多种疾病,对人体健康产生危害。该食品安全问题已引起国内外广泛关注,诸多研究表明双酚A可诱发肿瘤、影响生育等疾病,近年来又发现双酚A对记忆能力也有较大负面影响。本文从信号通路、突触可塑性与结构修饰、表观遗传修饰的改变等方面阐述双酚A对动物海马区记忆功能的影响及其机制方面的研究进行综述,以引起广大相关研究者的重视,并为食品安全防范提供科学依据。Bisphenol A can migrate into food through the plastic food packaging materials, and be absorbed by body, inducing diseases and health hazard. BPA has been a focus of food safety. Many studies have illustrated that bisphenol A can induce tumors, fertility and other diseases. In recent years, bisphenol A has been found harmful to memory capacity. Therefore, this paper summarized the recent studies about the effect of BPA on memory function and aimed to explain the mechanisms through the signal pathway, plasticity, structural modification, and the changing of epigenetic modification. The main purpose of this review was to attract the attention of relevant researchers and provide scientific science for food safety.

关 键 词：双酚A 记忆功能 研究进展 

分 类 号：R284.1[医药卫生—中药学]