β-羰基酸与N-Boc靛红亚胺的脱羧Mannich反应合成3-氨基-3,3'-二取代氧化吲哚衍生物  

Synthesis of 3-Amino-3,3'-disubstituted Oxindole Derivatives by The Decarboxylic Mannich Reaction of β-Carbonyl Acids and N-Boc Isatin Imines

作　　者：崔宝东 袁昌伦[1] 单静[1] 陈永正[1] 

机构地区：[1]遵义医学院药学院,贵州遵义563000

出　　处：《合成化学》2017年第8期642-647,共6页Chinese Journal of Synthetic Chemistry

基　　金：贵州省高校优秀科技创新人才支持计划项目(黔教合KY字[2015]480)

摘　　要：以5 mol%辛克宁衍生的手性双功能硫脲叔胺为催化剂,β-羰基酸和N-Boc靛红亚胺为原料,经脱羧Mannich反应合成了14个3-氨基-3,3'-二取代氧化吲哚衍生物,收率73%~99%,其结构经1H NMR,13C NMR和HR-MS(ESI)确证。An efficient decarboxylic Mannich reaction of β-carbonyl acids and N-Boc isatin imines with the chiral bifunctional thiourea-tertiary amine catalyst derived from einchonine was realized. Fourteen 3-amino-3,3＇-disubstituted oxindole derivatives were synthesized with yields of 73% ～ 99%. The structures were confirmed by ^1H NMR, ^13C NMR and HR-MS（ESI） analysis.

关 键 词：有机催化 N-Boc靛红亚胺 Mannich反应 3-氨基-3 3'-二取代氧化吲哚 合成 

分 类 号：O626.2[理学—有机化学]