河南农村1227名成年人静息活动时间与2型糖尿病发病风险的关联研究  

Association between the time of sedentary behaviors and risk of type 2 diabetes

作　　者：史园园[1] 李玉倩[2] 王瑾瑾[3] 王重建[1] 赵景志 尹磊 樊静静[1] 周雯[1] 李琳琳[1] 

机构地区：[1]郑州大学公共卫生学院,450000 [2]郑州大学药学院,450000 [3]河南中医药大学基础医学院 [4]河南省军区医院预防保健科

出　　处：《中华预防医学杂志》2017年第8期734-739,共6页Chinese Journal of Preventive Medicine

基　　金：国家自然科学基金（81502879）

摘　　要：目的 分析河南省农村成年人静息活动时间与2型糖尿病（T2DM）发病间的关系.方法 在河南省郑州市侯寨和焦作市乔庙乡两地招募1227名成年人作为研究对象,进行问卷调查、体格检查和生化指标检测,根据是否患T2DM将研究对象分为病例组和对照组.采用Pearson线性相关和线性回归模型分析静息活动时间和FPG的关联,采用多因素logistic回归模型分析静息活动时间与T2DM的关联性.结果 研究对象FPG为（5.4±2.5）mmol/L,静息活动时间为（234.5±156.5）min/d;静息活动时间为0~〈2.5、2.5~〈4.5、4.5~〈6.5和≥6.5 h/d的研究对象T2DM患病率分别为15.8%（72/457）、19.3%（73/379）、16.7%（35/210）和20.4%（37/181）.静息活动时间（x）和FPG（y）之间存在线性回归关系,线性回归方程为：y=5.081＋0.001x（t=3.01,P=0.003）.调整性别、年龄后,与0~〈2.5 h/d组相比,静息活动时间≥6.5 h/d者T2DM的患病风险增加77%（OR=1.77,95%CI：1.11~2.81）;按性别和年龄分层后,仅在男性和≥50岁成年人中静息活动时间与T2DM存在关联,与0~〈2.5 h/d组相比,静息活动时间≥6.5h/d患T2DM的风险分别增加134%和122%,OR（95%CI）值分别为2.34（1.21~4.52）、2.22（1.19~4.16）.结论 较长的静息活动时间是T2DM的危险因素.按性别和年龄分层后,仅在男性和≥50岁成年人中,静息活动时间与T2DM存在关联性.Objective To explore the relationship between the time of sedentary behaviors and the risk of type 2 diabetes mellitus （T2DM） among rural adults in Henan Province. Methods A total of 1227 adults from Houzhai village in Zhengzhou City and Qiaomiao village in Jiaozuo City in Henan Province were randomly selected to participate in the survey; each of them finished a questionnaire and accepted physical examination and test of biochemical indicators. The participants were divided into case and control groups according to whether suffering from T2DM. A Pearson linear correlation and linear regression model analysis were used to investigate the relevance between the time of sedentary behaviors and fasting plasma glucose （FPG）; meanwhile, a multi factor logistic regression model was used to analyze the relationship between the time of sedentary behaviors and T2DM. Results The average FPG level among the participants was （5.4± 2.5） mmol/L, and the average time of sedentary behaviors was （234.5±156.5） min per day. The prevalence rate of T2DM in subgroups whose time of sedentary behaviors were separately 0-〈2.5, 2.5-〈4.5, 4.5-〈6.5 and ≥6.5 h/day were 15.8% （72/457）, 19.3% （73/379）, 16.7% （35/210） and 20.4% （37/181）, respectively. There was a linear regression relationship between the time of sedentary behaviors（x） and FPG（y）, the regression equation was： y=5.081＋0.001x （t=3.01, P=0.003）. Logistic regression model analysis showed that participants whose time of sedentary behaviors ≥6.5 h/day had significantly higher risk of T2DM than those whose time of sedentary behaviors between 0-2.4 h/day （OR=1.77, 95%CI： 1.11-2.81） after age and gender adjusted. However, the associations only exist in males and adults ≥50 years old according to sex and age stratification. It showed that participants with sedentary time ≥6.5 h /day had significantly higher risk of T2DM than those with sedentary time between 0-〈2.5 h/d, with the corresponding OR （95%CI） at 2.34 �

关 键 词：糖尿病  2型 病例对照研究 静息活动时间 

分 类 号：R587.1[医药卫生—内分泌]