间充质干细胞应用于肝移植的研究进展  

Research Progress of Mesenchymal Stem Cells in Liver Transplantation

作　　者：陈榕[1] 王轩[1] 

机构地区：[1]解放军第八一医院肿瘤外科,南京210002

出　　处：《医学综述》2017年第16期3146-3150,共5页Medical Recapitulate

基　　金：南京军区医学科技创新课题(14ZX07)

摘　　要：肝移植是挽救终末期肝病患者的一个重要手段,其术后需长期使用免疫抑制剂以降低急性排斥反应的发生率。目前,制约移植患者远期生活质量的主要问题是慢性排斥反应和长期使用免疫抑制剂所伴随的不良反应,如何有效预防慢性排斥反应的发生及减少免疫抑制剂所带来的不良反应已成为移植领域的一项难题。间充质干细胞具有免疫抑制和改善组织生物学功能的特性,对器官移植后机体的免疫调节和功能恢复具有一定促进作用。若能将其成功应用于肝移植患者,不仅有望提高边缘性供肝的利用率、拓宽供肝来源,还可能为肝移植术后难治性并发症提供全新的治疗手段。Liver transplantation is an important method to save patients with end-stage liver disease, and long-term use agents after liver transplantation is needed to reduce the incidence of acute rejection. At present, the main problems of restricting the long-term quality of life of transplant patients are chronic rejection and long-term use of immunosuppressive agents associated adverse reactions, therefore, how to effectively prevent the occurrence of chronic rejection and reduce the adverse effects of immunosuppressive agents has become a problem in the field of transplantation. Mesenchymal stem ceils have the characteristics of immunosuppression and improving the biological function of tissues, which can promote the immunoregulation and functional recovery after organ transplantation. If it can be successfully applied to patientswith liver transplantation, it is expected not only to improve the utilization of marginal donor liver, broaden the source of liver, but also provide a new treatment for intractable complications after the liver transplantation.

关 键 词：肝移植 间充质干细胞 免疫调节 

分 类 号：R392.4[医药卫生—免疫学]