脓毒症定义和诊断标准的演进  

Evolution of Definition and Diagnostic Criteria of Sepsis

作　　者：陈晓洁[1] 董天皞[1] 张桂萍[1] 刘斯[1] 王起运[1] 贺星[1] 董凯[1] 

机构地区：[1]天津红日药业股份有限公司,天津301700

出　　处：《医学综述》2017年第16期3230-3235,共6页Medical Recapitulate

基　　金：天津市科技小巨人领军企业培育重大项目(14ZXLJSY00230)

摘　　要：脓毒症作为威胁生命的综合征,其发病机制复杂,是重症患者死亡的主要原因之一。自20世纪90年代初"脓毒症"概念提出以来,经历了"脓毒症-1"到"脓毒症-3"定义的演进,但是前两次定义的基本核心并无变化。2016年,第45届美国重症医学年会发布了"脓毒症-3"新定义及相应的临床诊断标准,将脓毒症定义为针对感染的宿主反应失调引起的致命性器官功能障碍。脓毒症-3是基于学者们对脓毒症本质有了更加深刻的理解而提出的,体现了人类对脓毒症发病机制的深入认识,满足了诊断标准合理化、临床诊断准确化和便捷化的需要。Sepsis, a life-threatening syndrome with a complex pathogenesis, is one of the leading causes of death among severe eases. Since sepsis defined in 1990s, the evolution of sepsis definition has experienced from sepsis-1 to sepsis-3 ,but there was no change in basic cores of sepsis-1 and sepsis-2. In 45th Critical Care Congress of the Society of Critical Care Medicine＇s（SCCM） in 2016, sepsis-3 was defined as life-threatening organ dysfunction caused by a dysregulated host responseto infection. Sepsis-3 not only reflected the deeper understanding of the pathogenesis of sepsis ,but also met needs of rationalized diagnostic criteria, accurate and convenient clinical diagnosis.

关 键 词：脓毒症 脓毒症-1 脓毒症-2 脓毒症-3 诊断标准 感染 

分 类 号：R631[医药卫生—外科学]