中药膜技术的“绿色制造”特征、国家战略需求及其关键科学问题与应对策略  

“Green manufacture” characteristics and national strategic demand of Chinise materia medica membrane technology and its key scientific problems and countermeasures

作　　者：郭立玮[1,2] 邢卫红[3] 朱华旭[1,2] 高从堦[4] 唐志书[5] 丁菲[6] 杨积衡 孙静[5] 李博[1,2,8] 

机构地区：[1]南京中医药大学江苏省中药资源产业化过程协同创新中心,江苏南京210023 [2]南京中医药大学江苏省植物药深加工工程研究中心,江苏南京210023 [3]南京工业大学特种分离膜国家工程研究中心,江苏南京210009 [4]浙江工业大学,浙江杭州3100145 [5]陕西中医药大学陕西省中药资源产业化过程协同创新中心,陕西咸阳7120466 [6]扬子江药业集团南京海陵中药制药工艺技术国家工程研究中心,江苏南京2100237 [7]江苏久吾高科技股份有限公司无机膜国家地方联合工程研究中心,江苏南京2118088 [8]南京中医药大学第一临床医学院,江苏南京210023

出　　处：《中草药》2017年第16期3267-3279,共13页Chinese Traditional and Herbal Drugs

基　　金：2017中国工程院咨询项目(2017-XZ-08);国家自然科学基金资助项目(30572374;30171161;30873449);国家科技部"十五"科技攻关计划项目(2004BA721A42);国家科技部"十一五"科技支撑计划项目(2006BAI09B07-03)

摘　　要：中医药是我国具有原创优势的科技领域,中医药继承创新研究已被提升为国家科技战略。膜技术适应中药药效物质整体、多元特征的优势,可充分实现中药资源的核心价值;并具高效、节能、无污染等特点。中医药膜科技具有重大国家科技战略需求,是我国中药制药工业亟需推广的高新技术。紧密围绕膜技术在中药制药工业的产业化应用,对所开展的中药绿色制造关键技术研究——"基于膜过程的中药制药分离工程技术体系与应用"进行概述,针对中药工业生产中制剂前处理环节存在的生产效率低、药材利用率低、能耗大、污染高、灭菌效率低等共性问题,基于中成药生产过程特点、工程原理和规律,以膜科学技术为核心,通过构建"中药溶液环境"科学假说,引进复杂系统科学原理,建立基于计算机化学方法的中药膜传质过程研究方法;针对中药膜技术工程化应用瓶颈,构建面向中药物料的"膜过程优化"技术集成等策略,开展中成药生产中节能、降耗、减排、工艺优化等关键技术与装备的研发,形成基于膜过程的具有自主知识产权的中药绿色制造系列关键共性技术,建立符合中药特点的环境友好生产线,实现了中药工业生产中制剂前处理"提取、精制、浓缩"等环节的高效、环保、稳定与智能控制。中药膜技术以水为基本溶剂,可保留中医传统用药特色,所研制的膜技术及其成套设备已推广至全国29个省市,产生了显著的社会和经济效益。膜技术完全符合建设资源节约型和环境友好型社会,以及循环经济的发展思路,是名副其实的中药绿色制造关键技术,对推动我国中药制药行业的技术进步,提升劳动生产率和资源利用率具有重要作用,具有广阔的推广应用前景。Traditional Chinese medicine（TCM） is China＇s original advantages of the field of science and technology. TCM inheritance innovation research has been promoted to national science and technology strategy. Membrane technology is adapt to the efficacy and advantages of multiple features of Chinise materia medica（CMM） substance, which can fully realize the core value of CMM resources, and it has high efficiency, energy saving, pollution-free features. The use of membrane technology in TCM is the high-tech that needs to be promoted. This paper summarized the authors＇ study for more than 10 years, focusing on ＂CMM pharmaceutical separation engineering technology system and application based on membrane process＂. In order to solve the problems of low production efficiency, high energy consumption, high pollution and low sterilization efficiency, membrane technology is taken as the core. Through the construction of ＂CMM solution environment＂ scientific hypothesis, computer chemistry established based on CMM film mass transfer process research methods; According to the bottleneck of engineering application of membrane technology in CMM, CMM green manufacture series of key common technology was established. The establishment of characteristics of CMM in line with the characteristics of environmentally friendly production lines to achieve the CMM production in the preparation of ＂extraction, refining, enrichment＂ and other aspects of efficient, environmentally friendly, stable and intelligent control. CMM＇s membrane technology takes water as the basic solvent, which can retain the CMM＇s characteristics; The membrane technology and its sets of equipment have been extended to 29 provinces nationwide, resulting in significant social and economic benefits. Of which the production cycle of the product unit is shortened, the energy consumption is reduced, the resource utilization rate is increased, the labor productivity is increased, the retention rate of the main indicator component is more than 95%;

关 键 词：中医药 国家科技战略 绿色制造 膜科技 产业升级 

分 类 号：R283.3[医药卫生—中药学]