正交试验法优选复方青风藤巴布剂的基质处方  

Optimization of matrix prescription of Compound Qingfengteng Cataplasm by orthogonal test method

作　　者：林欣媛 储晓琴[1,2] 桂双英[1,2,3] 

机构地区：[1]安徽中医药大学,安徽合肥230012 [2]安徽省中医药科学院药物制剂研究所,安徽合肥230012 [3]新安医学教育部重点实验室,安徽合肥230012

出　　处：《中草药》2017年第16期3347-3352,共6页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(81274099)

摘　　要：目的优选复方青风藤巴布剂(CQC)的基质处方。方法以综合感官为评价指标,对基质的种类和用量进行单因素试验;在单因素考察结果的基础上结合初黏力和持黏力指标,采用正交试验法优选CQC基质处方;并采用Franz扩散池法进行体外透皮吸收实验筛选促渗剂。结果优选CQC的基质处方为聚丙烯酸钠(NP-700)2.5 g,甘油11 g,甘羟铝0.08g,酒石酸0.08 g,聚乙烯吡咯烷酮(PVP)K90 0.8 g,交联聚乙烯吡咯烷酮(PVPP)0.5 g,水20 g,干浸膏4.2 g;以3%氮酮作为促渗剂时促渗效果较好。结论优选的基质处方切实可行,制备的CQC黏着力适中,无残留,膏体性状、皮肤追随性均良好。Objective To optimize the matrix prescription of Compound Qingfengteng Cataplasm（CQC）. Methods Taking the comprehensive senses as evaluation index, the types and dosage of the matrix were investigated by single factor. Further combined with the initial viscosity and holding viscosity index to optimize the matrix prescription of CQC by orthogonal test, and in vitro transdermal absorption experiments were carried out by Franz diffusion pool method to screen penetration enhancers. Results The optimal formulation of CQC was as follows： 2.5 g of NP-700, 11 g of glycerin, 0.08 g of glycine aluminum, 0.08 g of tartaric acid, 0.8 g of PVP K90, 0.5 g of PVPP, 20 g of water, and 4.2 g of dry extract. 3% nitrile as a penetration agent could enhance penetration action. Conclusion The preferred matrix prescription is practicable; CQC adhesion is moderate, no residue, paste traits, skin followability are good.

关 键 词：复方青风藤 巴布剂 单因素实验 正交试验 基质处方 促渗剂 

分 类 号：R283.6[医药卫生—中药学]