浙江七叶树种子的化学成分研究  

Chemical constituents from seeds of Aesculus chinensis

作　　者：魏书香 王桐[1,2,3] 丁丽琴[2,3] 邱峰[1,3] 

机构地区：[1]天津中医药大学中药学院,天津300193 [2]天津中医药大学中医药研究院,天津300193 [3]天津市现代中药重点实验室,天津300193

出　　处：《中草药》2017年第15期3026-3031,共6页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金重点项目(81430095)

摘　　要：目的对浙江七叶树Aesculus chinensis var.chekiangensis种子的70%乙醇提取物进行化学成分研究。方法采用D101大孔吸附树脂柱色谱、正相硅胶柱色谱、Sephadex LH-20柱色谱、反相高效液相色谱等方法对浙江七叶树种子的化学成分进行分离纯化,并根据理化性质和波谱数据等鉴定其结构。结果从浙江七叶树种子中共分离得到10个化合物,分别鉴定为2R,3R-3,7,3′-三羟基-5′-甲氧基二氢黄烷-5-O-β-D-葡萄糖苷(1)、槲皮素-4′-O-β-D-葡萄糖苷(2)、槲皮素-3′-O-β-D-葡萄糖苷(3)、槲皮素-3-O-[β-D-木糖基(1-2)]-β-D-葡萄糖苷(4)、槲皮素-3-O-[β-D-吡喃葡萄糖(1-4)]-α-L-吡喃鼠李糖苷(5)、山柰酚-3-O-[β-D-吡喃葡萄糖(1-4)]-α-L-吡喃鼠李糖苷(6)、山柰酚-3-O-[β-D-木糖基(1-2)]-β-D-葡萄糖苷(7)、山柰酚-3-O-[β-D-木糖基(1-2)][β-D-葡萄糖基(1-3)]-β-D-葡萄糖苷(8)、(-)-表儿茶素(9)、槲皮素(10)。结论化合物1、2为首次从七叶树属植物中分离得到,化合物3~9为首次从浙江七叶树种子中分离得到。Objective To study the chemical constituents from the 70% ethanolic extracts of Aesculus chinensis seeds. Methods The compounds were isolated by D101 macroporous adsorptive resins, silica gel, Sephadex LH-20, and preparative-HPLC and their structures were identified by chemical methods and spectroscopic analyses. Results Ten compounds were isolated from the 70% ethanolic extracts of A. chinensis seeds. They were 2R,3R-3,7,3′-trihydroxy-5′-methoxyflavane-5-O-β-glucopyranoside（1）, quercetin-4′-O-β-D-glucopyranoside（2）, quercetin-3′-O-β-D-glucoside（3）, quercetin-3-O-[β-D-xylopyranosyl（1-2）]-β-Dglucopyranoside（4）, quercetin-3-O-[β-D-glucopyranosyl（1-4）]-α-L-rhamnopyranoside（5）, kaempferol-3-O-[β-D-glucopyranosyl（1-4）]-α-L-rhamnopyranoside（6）, kaempferol-3-O-[β-D-xylopyranosyl（1-2）]-β-D-glucopyranoside（7）, kaemferol-3-O-[β-Dxylopyranosyl（1-2）] [β-D-glucopyranosyl（1-3）]-β-D-glucopyranoside（8）,（-）-epicatechin（9）, and quercetin（10）. Conclusion Compounds 1 and 2 are obtained from genus Aesculus Linn. for the first time, and compounds 3—9 are isolated from A. chinensis for the first time.

关 键 词：七叶树属 浙江七叶树 2R 3R-3 7 3′-三羟基-5′-甲氧基黄烷-5-O-β-D-葡萄糖苷 槲皮素-4′-O-β-D-葡萄糖苷 (-)-表儿茶素 

分 类 号：R284.1[医药卫生—中药学]