不同剂量蛋白质饮食对Ⅱ期压疮愈合及血清白蛋白、血红蛋白影响的实验研究  

Experimental study on different doses of protein diet on stage Ⅱ pressure ulcer healing,serum albumin and hemoglobin

作　　者：张亚楠[1] 李贤[2] 王瑶[2] 赵志红[2] 高文娟[2] 郑美洁[2] 吴晓娇[2] 

机构地区：[1]承德医学院 [2]河北省人民医院

出　　处：《护理研究（上旬版）》2017年第9期3102-3105,共4页Chinese Nursing Researsh

基　　金：河北省卫生卫计委医学科学研究重点课题;编号:20160463

摘　　要：[目的]研究不同剂量的蛋白质饮食对大鼠Ⅱ期压疮模型创面愈合时间、血红蛋白和血清白蛋白的影响。[方法]将100只大鼠完全随机分为对照组(含4g蛋白质的标准鼠粮)、实验1组(2g蛋白质)、实验2组(3g蛋白质)、实验3组(5g蛋白质),采用磁铁压迫持续缺血损伤复制大鼠Ⅱ期压疮模型,造模成功后每组每天分别给予4种蛋白含量的饮食干预,在造模后第1天、第3天、第7天、第14天测量大鼠的压疮面积、体重,并在每个时间段从每组随机抽取3只大鼠腹主动脉取血测量血红蛋白和血清白蛋白的含量。[结果]对照组压疮愈合时间最短,实验1组愈合时间最长,4组都在压疮发生后的前一个星期愈合最快,实验1组、实验2组血红蛋白和血清白蛋白持续下降。[结论]蛋白质対压疮愈合时间有影响,基础饮食最利于Ⅱ期压疮创面愈合,且不会引起体内蛋白质含量的变化。Objective:To explore the effects of different doses of protein diet on wound healing time of stageⅡpressure ulcer,hemoglobin and serum albumin in rats.Methods:A total of 100 rats were randomly divided into control group(standard rat food containing 4g protein),experimental group one(2g protein),experiment group two(3g protein),and experiment group three(5g protein).The rats were treated with magnetic compression and continuous ischemic injury to copy the model of stageⅡ pressure ulcer.When the model finished,the rats were treated with four kinds of protein contents in each group every day.On the first day,the third day,the seventh day,and fourteenth day when the model finished,the pressure sores area and body weight of rats were measured,and the contents of hemoglobin and serum albumin at abdominal aorta were measured from 3random rats' from each group at each time.Results:The healing time was the shortest in control group and the longest in experimental group 1.The four groups had the fastest healing at the first week after the occurrence of pressure ulcer.The hemoglobin and serum albumin were continually decreasing in experimental group one and the experimental group two.Conclusions:The healing time was affected by protein.The basic diet was the most beneficial to the stageⅡ pressure ulcer healing and did not cause the change of the protein content in the body.

关 键 词：压疮 不同剂量 蛋白质 饮食干预 愈合时间 血红蛋白 白蛋白 实验研究 

分 类 号：R47[医药卫生—护理学]