瑶药白花丹炮制前后白花丹醌含量测定及小鼠急性毒性试验  

Comparative study on content of plumbagin and Acute toxicity of Yao medicine “Plumbago zeylanica” and its processed products

作　　者：赵湘培 陈少锋 余胜民 钟鸣[2] 

机构地区：[1]广西壮族自治区民族医药研究院,广西南宁530001 [2]广西中医药研究院,广西南宁530012

出　　处：《中国民族医药杂志》2017年第8期46-49,共4页Journal of Medicine and Pharmacy of Chinese Minorities

基　　金：广西壮族自治区卫生厅中医药科技专项课题(GZBZ14-13);广西科学研究与技术开发计划课题(No.桂科能14123006-6)

摘　　要：目的:比较白花丹生品及炮制品的白花丹醌含量及急性毒性大小,为探讨白花丹炮制机理提供依据。方法:采用测定半数致死量的方法对白花丹生品及炮制品的急性毒性进行研究;采用高效液相色谱法测定白花丹生品及炮制品中的白花丹醌的含量。结果:白花丹生品及炮制品的LD50分别为88.7 g/kg、99.5 g/kg,其白花丹醌的质量分数分别为0.0136%、0.0041%。结论:白花丹炮制后急性毒性显著降低,表明用炮制能减少白花丹醌的含量,降低白花丹的毒性。Objective： To compare the content of plumbagin and the acute toxicity of Yao medicine ＂Plumbago zeylanica＂ and its processed products. Method： HPLC method was used to determine the content of plumbagin, and the classical method of acute toxicity was used to evaluate the acute toxicity of the Plumbago zeylanica and its processed products. Result： The content of plumbagin on Plumbago zeylanica and its processed products was separately 0.0136% and 0. 0041%, and the MLD were respectively 88.7 and 99.5 g/kg. Conclusion： Proceeding has certain influence on the content of plumbagin and acute toxicity of plumbago zeylanica.

关 键 词：白花丹 炮制 白花丹醌 急性毒性 

分 类 号：R295.1[医药卫生—民族医学]