肾病型肠内营养制剂对维持性血液透析合并营养不良患者营养状态、微炎症状态的影响  

Effect of nephrotic enteral nutrition preparation on nutritional status and microinflammatory state in patients with maintenance hemodialysis complicated by malnutrition

作　　者：兰传英 唐利[1] 

机构地区：[1]四川省自贡市第三人民医院肾病内科,四川自贡643020

出　　处：《海南医学院学报》2017年第13期1791-1793,1797,共4页Journal of Hainan Medical University

基　　金：自贡市科技局课题项目(2013ZC27)~~

摘　　要：目的:探讨肾病型肠内营养制剂对维持性血液透析合并营养不良患者营养状态、微炎症状态的影响。方法:收集在本院接受维持性血液透析治疗且出现营养不良的患者68例,随机分为对照组及观察组各34例。对照组接受常规饮食干预,观察组在常规干预的基础上加入肾病型肠内营养制剂。对比两组干预前后营养状态、微炎症状态的影响。结果:干预前,两组外周血中蛋白指标及微量元素、血清中炎症因子含量的差异无统计学意义(P>0.05)。干预后,观察组外周血中营养相关蛋白TP、ALB、PA、Hb、TRF的含量高于对照组;外周血中微量元素Zn、Fe的含量高于对照组,Ca的含量低于对照组;血清中炎症因子IL-6、hs-CRP、TNF-α的含量低于对照组(P<0.05)。结论:肾病型肠内营养制剂可有效优化维持性血液透析合并营养不良患者的营养状态,降低微炎症程度。Objective：To study the effect of nephrotic enteral nutrition preparation on the nutritional status and microinflammatory state in patients with maintenance hemodialysis complicated by malnutrition.Methods：A total of 68 patients who received maintenance hemodialysis and had malnutrition in our hospital between January 2013 and July 2016 were collected and divided into control group（n=34）and observation group（n=34）according to random number table.Patients in control group received regular dietary intervention while observation group received nephrotic enteral nutrition preparation based on routine intervention.Nutritional status and microinflammatory state before and after intervention were compared between two groups of patients.Results：Before intervention,the differences in peripheral blood levels of protein indexes and trace elements as well as serum levels of inflammatory factors were not statistically significant between two groups of patients（P〉0.05）.After intervention,peripheral blood nutrition-related proteins TP,ALB,PA,Hb and TRF levels of observation group were significantly higher than those of control group（P〈0.05）;peripheral blood trace elements Zn and Fe levels were significantly higher than those of control group while Ca level was significantly lower than that of control group（P〈0.05）;serum inflammatory factors IL-6,hs-CRP and TNF-αlevels were significantly lower than those of control group（P〈0.05）.Conclusions：Nephrotic enteral nutrition preparation can effectively optimize nutritional status and reduce microinflammation degree in patients with maintenance hemodialysis complicated by malnutrition.

关 键 词：维持性血液透析 营养不良 肾病型肠内营养制剂 营养状态 微炎症状态 

分 类 号：R692[医药卫生—泌尿科学]