黏膜免疫佐剂的研究进展  

Progress in mucosal adjuvant

作　　者：李振宇[1] 胡四海[1] 

机构地区：[1]南华大学病原生物学研究所,湖南衡阳421001

出　　处：《微生物学免疫学进展》2017年第4期65-69,共5页Progress In Microbiology and Immunology

基　　金：国家自然科学基金(81172890)

摘　　要：佐剂对于增强疫苗的免疫效果以及改变免疫应答类型发挥着非常重要的作用。然而,在人用疫苗中可使用的佐剂数量有限,尤其是有效的黏膜免疫佐剂缺乏。黏膜免疫佐剂能有效提高抗原的免疫原性,减少抗原用量或免疫接种次数,促进抗原提呈细胞的提呈作用,从而增强特异性免疫应答;但黏膜免疫佐剂安全性、有效性、免疫效力仍未达到理想的效果,需进一步深入研究。就目前常用的几种黏膜免疫佐剂的研究进展作一综述。Adjuvants play significant roles in strengthening and changing the antigen-specific immune response. However,there are only a limited number of adjuvants are used in human vaccination,especially,lacking of effective mucosal adjuvants. The effect of mucosal adjuvants is to enhance the immunogenicity for antigen and to decrease the immunization dose as well as times.Importantly,the mucosal adjuvants can strengthen the antigen-specific immune response by promoting antigen presentation. However,the further study is required since adjuvant safety and efficacy is not desirable in application.Here,we briefly review the research progress concerning the commoenly used mucosal adjuvants.

关 键 词：黏膜 佐剂 疫苗 免疫效果 

分 类 号：R392[医药卫生—免疫学]