基于蛋白信号转导网络的组分中药研究方法学  

Methodology Exploration for Multi-component Chinese Medicine Based on Protein Signal Transduction Network

作　　者：陈文星[1,2] 王旭[1,2] 王爱云[1,2] 陆茵[1,2] 

机构地区：[1]南京中医药大学药学院,南京210023 [2]江苏省中药药效与安全性评价重点实验室,南京210023

出　　处：《世界科学技术-中医药现代化》2017年第5期725-729,共5页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家自然科学基金委面上项目(81673725):利用"遗传协同致死"模式研究丹参微量弱效多成分的效应倍增机制;负责人:陆茵;国家自然科学基金委面上项目(81673648):基于Warburg效应探究破血药化瘀散结抑制肿瘤转移的分子基础;负责人:陈文星;江苏省"青蓝工程";负责人:陈文星;江苏省中药学优势学科(PKPD)

摘　　要：组分中药已被认为是中药复方用药的一个重要发展方向,但其方法学研究还处于创新阶段。现代医学认为导致疾病的因素多种多样,指示疾病的特征也是多样化,因而治疗疾病单从单一靶点入手有失偏颇,而针对多个靶点同时用药成为现代医学临床的共识。本方法基于中医证候的复杂性、蛋白信号转导通路网络的多靶点特性和中医方剂组方原则,提出一种简化的组分中药的筛选研究方法。并结合肿瘤的中医认识,以及现有中药有效成分抗肿瘤的研究成果,详细阐述该方法的具体运用。该方法可为中药效应成分的有效利用及新药发现拓展研究思路。Multi-component Chinese medicine has been considered an important developmental direction for traditionalChinese medicine（TCM） formula. Nowadays, it is unfit to target a molecule for preventing or curing a disease because itresulted from multiple of factors and resulted in many indications. Thus, the idea focusing on the multiple targets fortherapy is increasingly accepted by physicians and scientists. Here, we conceived a new simplified method for screeningthe active multi-component Chinese medicine based on the complexity of Chinese medicine, the multi-target property ofprotein signal transduction and the principle of Chinese medicine prescription. Combined with the traditional knowledgeon tumor and latest antitumor research results of Chinese medicine and its compounds, the method was concretelyillustrated. It helps us to transform the herbal compounds to new complex drugs targeting multiple signaling.

关 键 词：蛋白信号转导网络 方剂组方原则 组分中药 方法学 

分 类 号：R28[医药卫生—中药学]