骨组织支架的最新进展  

Recent advances of bone tissue scaffolds

作　　者：朱威[1] 王英杰[1] 马琦[1] 吴国梁[1] 翁习生[1] 

机构地区：[1]中国医学科学院北京协和医学院北京协和医院骨科,北京100730

出　　处：《中国骨与关节外科》2017年第2期163-168,共6页Chinese Journal of Bone and Joint Surgery

摘　　要：由于人口老龄化的加剧和社会人口年龄中位数的增加,骨科疾病引起了广泛的关注。移植骨是用于修复骨缺损的良好材料,但是有二次手术及骨量来源等诸多限制。而广泛应用于临床的骨植入物虽然在一定程度上提供了植入部位所需的机械强度、耐摩擦等性能,但由于其生物惰性,骨组织的生成不足,无法与骨组织形成紧密的骨性结合,导致不可避免的骨植入物松动。为了克服这些困难,现在的支架通常是多孔的、复合的。本文从多孔支架、微载体、植入物表面理化性质,植入物复合无机离子、细胞因子、干细胞等方面阐述新型支架内的组织生成。Because of the aggravation of the aging population and the increase of the median age of the population, orthopedic diseases have attracted more attention. Bone grafts are good materials for repairing bone defects, but there are many limitations such as the second operation and sources of bone mass. Bone implantsprovide enough mechanical strength and rub resistance for the implanted parts to a certain extent. However, due to the biological inertia of bone implants and insufficient bone tissue formation, bone implants can not form a close osseointegration with the bone tissue, resulting in the inevitable bone implant loosening. In order to overcome these disadvantages, the stent is usually porous and composite nowadays. In this paper, the novel scaffolds were described from the aspects of porous, micro-carriers, surface physical and chemical properties of implants, implanted inorganic ions, cytokines and stem cells.

关 键 词：多孔支架 微载体 细胞因子 干细胞 无机离子 

分 类 号：R318.08[医药卫生—生物医学工程]