沙棘提取物一般药理学实验研究  

Study on the general pharmacological effects of extracts of Shaji

作　　者：童东 魏志成[1] 左芳[1] 王丽[1] 罗煜[1] 孟宪丽[1] 曾勇[1] 

机构地区：[1]成都中医药大学药学院,中药材标准化教育部重点实验室,中药资源系统研究与开发利用省部共建国家重点实验室培育基地,四川成都611137

出　　处：《中药与临床》2017年第2期53-56,共4页Pharmacy and Clinics of Chinese Materia Medica

基　　金：四川省科技计划项目(2014SZ0071);四川省科技厅省青年科技创新研究团队专项计划项目(2014TD0007)

摘　　要：目的:为探讨沙棘提取物的安全性,观察沙棘提取物的一般药理作用,以供临床用药参考。方法:观察沙棘提取物对家犬血压、呼吸频率、呼吸振幅和心电图标准Ⅱ导联的影响,对小鼠自发活动的影响,对戊巴比妥钠阈剂量致小鼠睡眠时间的影响,对戊巴比妥钠阈下剂量致小鼠催眠有无明显协同作用,对小鼠的转棒运动有无明显的影响。结果:沙棘提取物在155 mg(原料药).kg^(-1)体重给药剂量内,对家犬心血管系统和呼吸系统均无明显影响;在754mg(原料药).kg^(-1)体重给药剂量范围内,对小鼠的中枢神经系统没有明显的抑制作用,对小鼠的机能协调运动也无明显影响。结论:一般药理作用研究表明,在上述剂量内沙棘提取物对动物心血管系统、呼吸系统及中枢神经系统均无明显影响,提示其不良反应小。Objective： To study the safety of extracts of Shaji and to observe the general pharmacological effects for the reference of clinical therapy. Method： The effects of extracts of Shaji on domestic dogs blood pressure, respiratory rate, respiratory amplitude, and electrocardiogram were observed. The effects of extracts of Shaji on mice spontaneous activity, sleeping time and hypnosis induced by pentobarbital sodium, and moving rod movement were observed. Result： With a dose of 155mg. kg-1, extracts of shaji had no obvious effect on cardiovascular systems and respiratory system of dog. With a dose of 754 mg. kg-~, it didn＇t inhibit the central nervous system and the coordination function of mice. Conclusion：The result indicates that with the above-mentioned dose of extracts of Shaji, it has no effect on animal＇s cardiovascular systems, respiratory system and central nervous system.

关 键 词：沙棘提取物 药理作用 心血管系统 呼吸系统 中枢神经系统 

分 类 号：R285.5[医药卫生—中药学]