吡格列酮联合二甲双胍治疗2型糖尿病的临床分析  

Clinical Analysis of Pioglitazone and Metformin in Treatment of Type 2 Diabetes

作　　者：郭晶[1] 

机构地区：[1]北京市门头沟区医院内分泌科,北京102300

出　　处：《系统医学》2017年第7期41-43,共3页Systems Medicine

摘　　要：目的观察吡格列酮联合二甲双胍治疗2型糖尿病的临床疗效。方法选取该院2016年1月—2017年1月收治的未经治疗2型糖尿病患者50例,将所有患者随机分为治疗组和对照组,每组各25例,对照组患者选用盐酸二甲双胍片,250 mg/片,1片/次,3次/d口服。治疗组患者在对照组的基础上加服盐酸吡格列酮,15 mg/片,1片/次,1次/d口服。所有患者接受治疗3个月,治疗前及治疗后测定静脉血浆血糖,采用葡萄糖氧化酶法测定;测定空腹血浆胰岛素水平,采用放射免疫分析法,同时静脉采血测定生化全套及血常规,观察疗效以及药物不良反应。结果治疗组患者25例,显效18例,有效6例,无效1例;总有效率为96.00%。对照组患者25例,显效10例,有效11例,无效4例;总有效率为86.00%。两组患者总有效率比较,差异有统计学意义(P<0.05),治疗组治疗后空腹血糖(7.1±1.3)mmol/L、餐后2 h血糖(8.1±1.9)mmol/L、空腹胰岛素(14.1±3.4)m U/L、糖化血红蛋白(7.1±1.3)%均优于治疗后对照组空腹血糖(7.9±1.6)mmol/L、餐后2 h血糖(9.1±2.1)mmol/L、空腹胰岛素(16.9±3.8)m U/L、糖化血红蛋白(7.4±1.6)%,差异有统计学意义(P<0.05)。结论吡格列酮联合二甲双胍治疗2型糖尿病的临床疗效良好,且安全性有效,值得临床推广。Objective To observe the clinical curative effect of pioglitazone and mefformin in treatment of type 2 dia- betes. Methods 50 cases of patients with type 2 diabetes but without treatment in our hospital from January 2016 to January 2017 were selected and randomly divided into two groups with 25 cases in each, the control group adopted the mefformin hydrochloride tablets, 250mg every tablet, 1 tablet every time, oral, three times daily, and the treatment group were treated with hydrochloride pioglitazone rosiglitazone on the basis of the control group, 15rag every tablet,1 tablet every time, oral, once every day, and all patients were treated for 3 months, and the venous plasma glucose was measured before and after treatment by the glucose oxidase assay, and the fasting plasma insulin level was measured by the radioactivity immune analysis method, and the curative effect and drug adverse reactions were observed. Results In the treatment group, 18 cases were markedly effective, 6 cases were effective, and 1 case was ineffective,and the total effective rate was 96.00%, in the control group, 10 cases were markedly effective, 11 cases were effective and 4 cases were ineffective, and the total effective rate was 86.00%, and the difference in the total effective rate was statistically significant （P〈0.05）, in the treatment group, the fasting blood glucose, blood glucose at 2h after dinner, fasting insulin and glycosylated hemoglobin after treatment were better than those in the control group [（7.1±1.3）mmo1/L, （8.1±1.9）mmol/L, （14.1±3.4）mU/L, （7.1±1.3）% vs （7.9±l.6）mmol/L, （9,1±2.1）mmol/L, （16.9±3.8）mUlL, （7.4±1.6）%], and the differences were statistically significant（P〈0.05）. Conclusion The clinical curative effect of pioglitazone and metformin in treatment of type 2 diabetes is good, and the safety is effective, which is worth clinical promotion.

关 键 词：吡格列酮 二甲双胍 2型糖尿病 

分 类 号：R587.1[医药卫生—内分泌]