富血小板血浆对干细胞增殖及分化作用的研究进展  

Study of the effect of platelet rich plasma on stem cell proliferation and differentiation

作　　者：谭金娣 陈福扬[1] 史欣[1] 赵芳[2] 姜建平[3] 胡伟平[1] TAN Jindi CHEN Fuyang SHI Xin ZHAO Fang JIANG Jianping HU Weiping(Second Affiliated Hospital of Harbin Medical Uni- versity, Department of Prosthodontics , Harbin 150001, China)

机构地区：[1]哈尔滨医科大学附属第二医院口腔修复科,黑龙江哈尔滨150001 [2]哈尔滨医科大学附属第二医院口腔牙体牙髓科,黑龙江哈尔滨150001 [3]哈尔滨医科大学附属第二医院口腔颌面外科,黑龙江哈尔滨150001

出　　处：《口腔医学》2017年第8期743-745,共3页Stomatology

基　　金：黑龙江省自然基金(H2013101)

摘　　要：干细胞具有高度的自我更新、增殖和多向分化的潜能,可通过细胞分裂维持自身细胞群的大小,同时又可进一步分化为各种组织的细胞,从而构成机体复杂的器官。然而干细胞数量少,含量低,解决间充质干细胞快速增殖能力是当今组织工程学研究的热点问题。富血小板血浆(platelet rich plasma,PRP)是自体全血经离心后得到的,含有大量血小板和少量的其他血细胞,PRP中含有的生长因子,如血小板衍生生长因子、胰岛素样生长因子和转化生长因子等可共同作用于干细胞,影响干细胞的增殖和分化。而且PRP还能克服异源性排斥的缺陷,并且价格低廉,生物安全性高,并发症少。因此了解PRP对干细胞增殖及分化具有重要的意义。Stem cells have highly self-renewal, proliferation and differentiation potential, through cell division to maintain the size of their cell mass, and can differentiate into various tissue cells at the same time, which constitute the complex body organ. However, stem ceils are rare, and the content is very low, so to solve the mesenchymal stem cell rapid proliferation is a hot issue in the research of tissue engineering. The platelet rich plasma （ Platelet rich, plasma, PRP） comes from the autologous blood after centrifugation, which contains a large number of platelets and a small quantity of other blood cells.Activated PRP can influence the proliferation of stem cell through the combined and synergistic effect of growth factors, such as platelet-derived growth factor, insulin-like growth factor and transforming growth factor and PRP can overcome the defects of Heterologous rejection, and has low price, high biological safety, and fewer complications. Therefore, it is important to understand the effect of PRP on the proliferation and differentiation of stem ceils.

关 键 词：富血小板血浆 干细胞 骨髓间充质干细胞 牙髓干细胞 

分 类 号：R329.28[医药卫生—人体解剖和组织胚胎学]