以中性粒细胞绝对值减少为主的儿童呼吸道EB病毒感染的临床特点分析  

Clinical characteristics of EBV of decreased absolute neutrophil count in children with respiratory tract infection

作　　者：刘韵[1] 张鸿彦[1] 徐燕霞[1] 李晓跃[1] 李佳泽[1] 高健[1] 

机构地区：[1]哈尔滨医科大学附属第一医院群力院区儿科,黑龙江哈尔滨150070

出　　处：《哈尔滨医科大学学报》2017年第3期247-249,共3页Journal of Harbin Medical University

摘　　要：目的探讨2015年哈尔滨地区儿童以中性粒粒细胞绝对值减少为主的EB病毒感染情况。方法收集分析2015年1~12月哈尔滨医科大学附属第一医院群力院区患呼吸系统疾病住院的儿童4 128例临床资料,采集血液通过ELISA法进行相关指标检测,对其EBV感染相关情况进行分析。结果2015年患呼吸系统疾病儿童中EBV感染率为41.71%,多发生于幼儿期及学龄前期;高发于2、11、12月份;EBV(+)患儿中性粒细胞绝对值减少占72.38%,常伴有Ig G、Ig A、C3、C4降低,并可引起ALT及CKMB升高,临床表现中以咽峡部脓苔为多见,重组人粒细胞巨噬细胞刺激因子缩短了ANC恢复正常值的时间。结论 2015年EBV感染有独特的中性粒粒细胞绝对值减少趋势,注射用重组人粒细胞巨噬细胞刺激因子在治疗中有较好的疗效。Objective To study EBV of decreased absolute neutrophil count （ANC） in chil- dren with respiratory tract infection of Harbin in 2015. Methods Data of 4 128 EBV of pa- tients in Qunli Branch of The First Affiliated Hospital of Harbin Medical University in 2015 were collected, blood collected by the ELISA method was used to detect the related indicators, the EBV infection related status were analyzed. Results The EBV of children with respiratory diseases in 2015 was 41.71%, develops in infancy and preschool period; high incidence in 2, 11, 12 months. Decreased ANC of 4 128 patients was 72.38%, often reduced IgG, IgA, C3 and （：4, elevating ALT and CKMB. Atrophic pharyngitis was the main manifestation, rhGM- CSF shortened the time of the ANC resume normal. Conclusion EBV in 2015 has a unique trend of decreased ANC. rhGM- CSF is safe and effective.

关 键 词：中性粒细胞绝对值 儿童 EBV 流行特征 临床研究 呼吸系统疾病 

分 类 号：R725.6[医药卫生—儿科]