5-甲基-1,3,4-噁二唑-2(3H)-酮的合成新方法  

New Synthesis Method of 5-Methyl-1,3,4-oxadiazol-2(3H)-one

作　　者：孙永明[1] 黄秋月[1,2] 端木传嵩[1] 何磊[1,2] 

机构地区：[1]淮阴工学院化学工程学院,江苏淮安223003 [2]江苏省盐化工新材料工程实验室,江苏淮安223003

出　　处：《山东化工》2017年第15期21-22,共2页Shandong Chemical Industry

基　　金：淮安市科技支撑项目(HAG2013018);江苏省青年科学基金(BK20130420)

摘　　要：以乙酸和水合肼为原料,经两步反应得到吡蚜酮的重要中间体5-甲基-1,3,4-噁二唑-2(3H)-酮。第一步反应中使用ZnCl_2/凹土固载催化剂,缩短了反应时间,提高了反应收率,第二步反应中使用Na_2CO_3为缚酸剂,环己烷为溶剂。总收率达83.4%。目标化合物经IR、~1HNMR确证。5- Methyl- 1,3,4- oxadiazol- 2 （3H） -one, an intermediate of pymetrozine for pesticide, was synthesized by two steps with acetic acid and hydrazine hydrate as raw materials. In step one, reaction time was reduced and the yield was increased by employing immobilized ZnCl2/attapulgite catalyst. In step two, Na2CO3 was employed as the acid -binding agent and cyclohexane was employed as the solvent. Under optimum conditions,the total yield was up to 83.4%. The target compound was confirmed by IR and 1HNMR.

关 键 词：-5-甲基-1 3 4-嘌二唑-2(3H)-酮 合成 吡蚜酮 

分 类 号：TQ252.4[化学工程—有机化工]