糖尿病胃轻瘫患者肠道菌群分布及炎症因子水平变化的观察  

Change of intestinal flora and inflammatory factors in patients with diabetic gastroparesis

作　　者：赵先群[1] 张雪松[2] 刘晓政[1] 张向东[1] 

机构地区：[1]南阳市中心医院消化二病区,473002 [2]南阳市中心医院儿科,473002

出　　处：《中国糖尿病杂志》2017年第8期725-728,共4页Chinese Journal of Diabetes

摘　　要：目的观察糖尿病胃轻瘫(DGP)患者肠道菌群的分布特点及炎症因子水平的变化。方法选取DGP患者(DGP组)126例、单纯糖尿病患者(DM组)100例及健康体检者(NC组)100名。收集各组一般资料和生化指标,检测肠道菌群数量和炎症因子水平。采用多元Logistic回归分析DGP的危险因素。结果 DGP组和DM组FPG、1hPG、2hPG、3hPG及HbA1c均高于NC组(P<0.05或P<0.01),DGP组糖尿病病程、FPG、3hPG及HbA1c高于DM组,2hPG低于DM组(P<0.05);NC组、DM组和DGP组肠杆菌逐渐升高[(7.14±0.28)vs(10.26±0.90)vs(15.54±1.11)CFU/g],拟杆菌[(12.94±1.43)vs(9.45±1.68)vs(7.99±1.46)CFU/g]、双歧杆菌[(11.47±0.52)vs(8.06±0.48)vs(6.35±0.49)CFU/g]及乳酸杆菌[(10.52±0.68)vs(7.77±0.55)vs(5.31±0.42)CFU/g]逐渐降低(P<0.05或P<0.01);DGP组、DM组和NC组TNF-α、IL-6、IL-1β及C-RP逐渐降低,IL-10和IL-2逐渐升高(P<0.05或P<0.01);多元Logistic回归分析显示,糖尿病病程、HbA1c、肠杆菌、TNF-α、IL-6及IL-10是DGP的影响因素(P<0.05或P<0.01)。结论 DGP患者肠道益生菌减少、抗炎因子水平降低,致病菌增多,炎症因子水平升高。肠杆菌、TNF-α、IL-6及IL-10可能在DGP的发生发展中起重要作用。Objective To observe the characteristics of intestinal flora and inflammatory factors in patients with diabetic gastroparesis （DGP）. Methods 126 patients with DGP（DGP group）, 100 diabetes patients without DGP（DM group） and 100 health people （NC group） were selected in this study. The general characteristics and biochemical indexes were collected, and the levels of intestinal flora and inflammatory factors were tested. Related factors for DGP were analyzed by Logistic regression analysis. Results The levels of FPG, 1 hPG, 2 hPG, 3 hPG and HbA1 c were higher in DGP group and in DM group than in NC group（P〈0. 05 or P〈0. 01）. DM course, FPG, 3 hPG and HbAlc were higher,the 2 hPG were lower in DGP group than in DM group （P〈0. 05）. Form NC group, DM group to DGP group,the enterobacteriaceae were increased[-（7.14±0. 28） vs （10. 26±0. 90） vs （15. 54±1.11） CFU/g], and the baeteroides[（12.94±11 43） vs （9.45± 1.68） vs （7.99±1.46） CFU/g], bifidobaeterium[-（11.47±0. 52） vs （8.06±0.48） vs （6.35±0.49） CFU/g] and lactobacillus[（10. 52±0. 68） vs （7.77±0.55） vs （5.31±0. 42） CFU/g] were reduced（P〈0. 05 or P〈0.01）. In group DGP,group DM and group NC,the levels of TNF-α, IL-6, IL-10 and C-RP gradually decreased, and IL-10 and IL-2 increased gradually. Logistic regression analysis showed that DM course, HbAlc, Enterobacter, TNF-α, IL-6 and IL-10 were risk factors for DGP（P〈0.05 or P〈0. 01）. Conclusion The probiotics and anti-inflammatory cytokine are reduced,and pathogenic bacterium and pro-inflammatory cytokine are increased in patients with DGP. Enterobacter,TNF-α, IL-6 and IL 10 maybe play an important role in the occurrence and development of DGP.

关 键 词：糖尿病胃轻瘫 肠道菌群 炎症因子 

分 类 号：R587.2[医药卫生—内分泌]