乙型肝炎病毒感染患者HBV-DNA载量与血清及肝纤维化标志物的关系  

Correlation analysis between HBV-DNA load and HBV serum and liver fibrosis markers in patients with chronic hepatitis B virus infection

作　　者：陈琼[1] 陈蓉[1] 曾艺馨 王悦[2] 周馥叶 

机构地区：[1]贵阳护理职业学院护理系内科教研室,贵州贵阳550081 [2]贵州省人民医院内科,贵州贵阳550002 [3]贵州省武警总队医院内科,贵州贵阳550005

出　　处：《中华医院感染学杂志》2017年第15期3487-3489,3509,共4页Chinese Journal of Nosocomiology

基　　金：贵州省优秀科技教育人才省长专项基金项目(省专合字2009-38)

摘　　要：目的探讨乙型肝炎病毒(HBV)感染患者HBV-DNA载量与血清及肝纤维化标志物的相关性。方法选取2012年1月-2015年12月医院收治的86例HBV感染患者,按照HBV血清标志物分为A组(大三阳)21例、B组(小三阳)35例、C组(除外大小三阳的HBsAg+表型)24例、D组(抗体阳性及全阴)6例,根据HBVDNA载量分为5个级别分为<10~3 IU/ml组、10~3~10~5 IU/ml组、10~5~10~6 IU/ml组、10~6~10~8 IU/ml组和>10~8IU/ml组。结果 A组HBV-DNA载量显著高于B组和C组,差异有统计学意义(P<0.05);C组HBV-DNA载量显著高于B组(P<0.05);透明质酸(HA)随着HBV-DNA复制水平的增高而增高,5个不同级别HBV-DNA载量组两两比较差异有统计学意义(P<0.05);层粘连蛋白(LN)、Ⅲ型前胶原肽(PⅢP)、Ⅳ型胶原(CⅣ)在<10~3IU/ml组、10~3~10~5 IU/ml组、10~5~10~6 IU/ml组中随着患者血清HBV-DNA载量上升也随之递增,而在10~6~10~8 IU/ml组和>10~8 IU/ml组中随着血清HBV-DNA载量上升出现相对降低的现象。结论 HBV-DNA载量与HBV血清标志物不同模式组存在相关性,并与LN、PⅢP、CⅣ存在相关性,但不呈直线相关关系,与HA呈正相关。OBJECTIVE To investigate the correlation between HBV-DNA load and serum and liver fibrosis markers in patients with hepatitis B virus infection.METHODS A total of 86 patients with hepatitis B virus infection in our hospital from Jan.2012 to Dec.2015 were selected.According to HBV serum markers,patients were divided into group A（big Sanyang,21 cases）,group B（small Sanyang,35 cases）,group C（other HBsAg＋ phenotype,24 cases）,and group D（antibody positive and overcast,6 cases）.According to the HBV-DNA load,patients were divided into 5 levels：10-3 IU/ml group,10-3-10^5 IU/ml group,10^5-10^6 IU/ml group,10^6-10-8 IU/ml group,and 10-8 IU/ml group.RESULTS The HBV-DNA load in group A was significantly higher than that in group B and group C（all P〈0.05）.The HBV-DNA load in group C was significantly higher than that in group B（P〈0.05）.HA was increased with the increase of the HBV-DNA replication level,and there were significant differences of 5 different levels of HBV-DNA load groups compared with each other（all P〈0.05）.LN,PⅢP and CⅣwere increased with the increase of serum HBV-DNA load in（ 10-3 IU/ml）group,（10-3-10^5 IU/m）l group and（10^5-10^6 IU/ml）group of patients,while were decreased in（10^6-10-8 IU/ml）group and 10-8 IU/ml group with the increase of serum HBV-DNA load.CONCLUSION There is a correlation between HBV-DNA load and HBV serum markers,and a correlation between HBV-DNA load and LN,PⅢP and CⅣ,but not linear correla tion,and HBV-DNA load is positively correlated with HA.

关 键 词：乙型肝炎 HBV-DNA 血清标志物 肝纤维化 

分 类 号：R512.62[医药卫生—内科学]