胰岛素泵联合连续血糖监测系统强化治疗老年脆性糖尿病临床研究  

Clinical study of continuous subcutaneous insulin infusion combined with continuous blood glucose monitoring system in the treatment of elderly patients with fragile diabetes mellitus

作　　者：牛利红 张晓立[2] 

机构地区：[1]铜川矿务局中心医院内分泌科,陕西铜川727000 [2]南京中医药大学附属南京市中西医结合医院内分泌病科,江苏南京210014

出　　处：《内科理论与实践》2017年第3期194-197,共4页Journal of Internal Medicine Concepts & Practice

摘　　要：目的:探讨胰岛素泵联合连续血糖监测系统(双"C")强化治疗老年脆性糖尿病临床疗效差异。方法:选取我院2011年1月至2014年10月收治的老年脆性糖尿病患者共120例,采用随机区组法分为对照组(60例)和联合组(60例),分别采用联合胰岛素方案和在此基础上加用双"C"强化辅助治疗。比较2组患者血糖达标率、血糖达标时间、胰岛素用量、治疗前后血糖指标水平及低血糖发生率等。结果:联合组患者血糖达标率明显优于对照组,差异具有统计学意义[97%(58/60)比80%(48/60),P<0.05],血糖达标时间和胰岛素用量均明显优于对照组,差异具有显著意义[(3.46±0.95)d比(6.50±1.82)d,(31.55±4.61)U/d比(40.12±5.94)U/d,P<0.05],治疗后血糖指标水平明显低于对照组、治疗前,差异具有统计学意义[(5.15±0.51)mmol/L比(7.37±0.91)mmol/L,(5.48±1.55)mmol/L比(8.20±2.04)mmol/L,(5.33±1.48)mmol/L比(7.96±2.20)mmol/L,(4.90±1.46)mmol/L比(7.70±2.07)mmol/L,(4.75±1.22)mmol/L比(6.70±1.98)mmol/L,P<0.05]。联合组患者低血糖发生率明显低于对照组,差异具有统计学意义[2%(1/60)比12%(7/60),P<0.05]。结论:双"C"强化辅助联合胰岛素方案治疗老年脆性糖尿病可有效改善血糖控制效果,缩短血糖达标时间,减少胰岛素用量,且有助于降低低血糖发生风险。Objective To investigate the clinical efficacy of continuous subcutaneous insulin infusion combined with continuous blood glucose monitoring system（double ＂C＂） in the treatment of elderly patients with fragile diabetes mellitus.Methods One hundred and twenty elderly patients with fragile diabetes mellitus from January 2011 to October 2014 in our hospital were randomly divided into two groups：double ＂C＂ group（60 patients） and solely continuous subcutaneous insulin infusion group（control group,60 patients）.The rate of blood glucose compliance,time for reaching the blood glucose compliance,insulin dosage,levels of blood glucose before and after treatment and the incidence of hypoglycemia of the two groups were compared.Results The rate of blood glucose compliance in double ＂C＂ groups was significantly higher than that in control group [97%（58/60） vs 80%（48/60）,P〈0.05].Time for reaching the blood glucose compliance and insulin dosage in double ＂C＂ group were significantly lower than those in control group[（3.46±0.95） d vs（6.50±1.82） d,（31.55±4.61） U/d vs（40.12±5.94） U/d,P〈0.05].The level of blood glucose after treatment in double ＂C＂ group was significantly lower than that in control group [（5.15±0.51） mmol/L vs（7.37±0.91） mmol/L,P〈0.05].The incidence of hypoglycemia in double ＂C＂group was significantly lower than that in control group [2%（1/60） vs 12%（7/60）,P〈0.05].Conclusions Double ＂C＂ could efficiently improve the control of blood glucose,shorten the time for reaching the blood glucose compliance,decrease the insulin dosage and reduce the risk of hypoglycemia in the treatment of elderly patients with fragile diabetes mellitus.

关 键 词：胰岛素泵 动态血糖监测系统 脆性糖尿病 疗效 

分 类 号：R587.1[医药卫生—内分泌]