连续血液滤过对肿瘤术后合并肾衰患者炎性因子及预后的影响  

Effect of continuous venovenous hemofiltration on inflammation factors and prognosis in patients with cancer complicated with postoperative renal failure

作　　者：王晓静[1] 李宁[1] 高勇[1] 王鑫[1] 

机构地区：[1]河北省胸科医院ICU,石家庄050041

出　　处：《中国肿瘤临床与康复》2017年第8期921-923,共3页Chinese Journal of Clinical Oncology and Rehabilitation

基　　金：河北省科学技术研究与发展计划项目(20130442)

摘　　要：目的探讨连续血液滤过治疗对肿瘤术后合并肾功能衰竭患者炎性因子及临床预后的影响。方法选取2013年8月至2016年8月间河北省胸科医院收治的58例肿瘤术后肾功能衰竭行连续血液滤过治疗的患者,比较治疗前后患者肾功能、电解质、炎性因子[急性期反应蛋白(CRP),白细胞介素6(IL-6),白细胞介素10(IL-10),肿瘤坏死因子a(TNF-α)]、pH值和PaO_2血气指标状况。结果经连续血液滤过治疗后,患者血肌酐(141±92)μmol/L、尿素氮(13±9)mmol/L和血钾(3.9±1.5)mmol/L,均较治疗前显著下降,差异均有统计学意义(均P<0.05);治疗后,炎性因子CRP(14.5±3.5)μmol/L、IL-6(64.2±12.3)μmol/L、IL-10(57.1±10.3)μmol/L及TNF-α(217.1±16.7)μmol/L,均较治疗前明显降低,差异均有统计学意义(均P<0.05);治疗后,患者pH值(7.41±0.15)及PaO_2(114±12 mm Hg),较治疗前明显升高,差异均有统计学意义(均P<0.05)。结论连续血液滤过治疗肿瘤术后合并肾功能衰竭,疗效较好,且安全性高。Objective To investigate the effect of continuous venovenous hemofihration on inflam- mation factors and prognosis in patients with cancer complicated with postoperative renal failure. Methods A total of 58 patients with cancer complicated with postoperative renal failure who were treated with continuous venovenous hemofiltration at Hebei Chest Hospital from August 2013 to August 2016 were selected. The renal function, electrolyte, inflammation factors including C-reactive protein （ CRP）, interleukin （IL） -6, IL-10, tumor necrosis faetor-a （TNF-a）, pH value and Carbon dioxide partial pressure （PCO2） were compared be- fore and after the treatment. Results After continuous hemofiltration treatment, serum creatinine value （141 ±92 μmol/L ）, urea nitrogen （13±9μmol/L and potassium （3.9 ±1.5 mmol/L） were significantly lower in the than before treatment （ all P 〈 0. 05 ）. After the treatment, CRP CRP（14.5±3.5）μmol/L、IL-6（64.2±12.3）μmol/L、IL-10（57.1±10.3）μmol/L and TNF-α（217.1±16.7）μmol/L were significantly lower than before treatment （all P 〈 0. 05 ）. After treatment, pH （7. 41 ± 0. 15 ） and PaO2 （ 114 ± 12 mmHg） increased compared with pre-therapy （ all P 〈 0. 05 ）. Conclusion Continuous hemofihration can achieve good efficacy and safety in the treatment of cancer complicated with postoperative renal failure.

关 键 词：连续血液滤过 肿瘤 肾功能衰竭 

分 类 号：R692.5[医药卫生—泌尿科学] R730.5[医药卫生—外科学]