肝动脉灌注栓塞化疗联合微波凝固治疗肝癌的疗效观察  

Efficacy of hepatic arterial infusion chemoembolization combined with microwave coagulation therapy for liver cancer

作　　者：顾金生[1] 迟立杰[1] 高峰[2] 吴建华[2] 王琳[1] 霍峰[1] 王艳波[1] 李壮[1] 刘洪宇[2] 王琳娜[1] 

机构地区：[1]黑龙江绥化市第一医院肿瘤科,绥化152000 [2]黑龙江绥化市第一医院彩超室,绥化152000

出　　处：《中国肿瘤临床与康复》2017年第8期950-952,共3页Chinese Journal of Clinical Oncology and Rehabilitation

基　　金：黑龙江省卫生计生委立项科研课题(2014-112)

摘　　要：目的探讨肝动脉灌注栓塞化疗联合微波凝固治疗肝癌的临床疗效。方法选取2014年3月至2015年11月间绥化市第一医院收治的98例肝癌患者,采用随机数字表法分为观察组与对照组,每组49例。观察组患者在肝动脉灌注栓塞化疗基础上联合微波凝固治疗,对照组患者采用单纯肝动脉灌注栓塞化疗治疗。比较两组患者的临床疗效及复发情况。结果观察组患者的客观缓解率为61.2%,显著高于对照组的18.4%,两组组间差异有统计学意义(P<0.05)。观察组患者化疗毒性反应集中在Ⅰ度和Ⅱ度,明显轻于对照组,差异有统计学意义(P<0.05)。观察组患者1年、2年和3年生存率均略高于对照组,差异均有统计学意义(均P<0.05)结论肝动脉灌注栓塞化疗联合微波凝固治疗肝癌,疗效显著,能够明显提高患者的生活质量,降低术后复发风险,值得推广。Objective To explore the clinical efficacy of hepatic arterial infusion chemoemboliza- tion combined with microwave coagulation in the treatment of liver cancer. Methods Ninety-eight patients with liver cancer treated at Suihua First Hospital were selected from March 2014 to November 2015. Using a random number table, patients were divided into an observation group and a control group with 48 patients in each group. The observation group received hepatic arterial infusion chemoembolization combined with mi- crowave coagulation and the control group only received hepatic artery infusion chemoembolization. Treat- ment efficacy was compared between the two groups and the recurrence was recorded. Results Objective response rate was 61.2% for the observation group, which was significantly higher than 18.4% of the con- trol group （P 〈 0. 05 ）. For the observation group, the main chemotherapy toxicity was grade I and II, which was significantly milder than in the control group （ P 〈 0. 05 ）. In terms of postoperative survival, 1- year, 2-year and 3-year survival rate were slightly higher in the observation group than in the control group （ P 〈 0. 05 ）. Conclusion Hepatic artery chemoembolization combined with microwave coagulation therapy for liver cancer has remarkable efficacy, which can significantly improve quality of life and reduce the risk of postoperative recurrence. It deserves the clinical expansion.

关 键 词：肝动脉灌注栓塞化疗 微波凝固 肝肿瘤 

分 类 号：R735.7[医药卫生—肿瘤]