血清肌红蛋白、尿胱抑素C和尿视黄醇结合蛋白对早期糖尿病肾脏疾病诊断价值的研究  

Diagnosis value of serum myoglobin, urine cystatin C and urinary retinol binding protein on early diabetic kidney disease

作　　者：冯秀兰[1] 

机构地区：[1]广东省江门市人民医院检验科,529000

出　　处：《中国实用医刊》2017年第14期27-29,共3页Chinese Journal of Practical Medicine

摘　　要：目的 探讨早期糖尿病肾病患者中的血清肌红蛋白（Myo）、尿胱抑素C（Cyc-C）和尿视黄醇结合蛋白（RBP）的表达.方法 选取糖尿病正常白蛋白尿期（DM）26例、早期糖尿病肾病期（DN）22例、临床糖尿病肾病期（DKD）28例和正常对照组（NC）23例,分别检测Myo、RBP、血和尿Cyc-C,同时检测血清肌酐（CRE）,尿微量白蛋白（mALB）,并对结果进行统计分析.结果 DM组与NC组比较差异均未见统计学意义（P〉0.05）;DKD、DN组与NC组比较差异有统计学意义（P〈0.01）;血清Cyc-C、Myo和尿的RBP、Cyc-C联合检测阳性率比单项检测阳性率高,差异有统计学意义（P〈0.05）.结论 联合检测血清肌红蛋白（Myo）、尿胱抑素C（Cyc-C）和尿视黄醇结合蛋白（RBP）对糖尿病肾病的早期诊断有重要意义.Objective To investigate the expression of myoglobin（Myo）, urinary cystatin C（Cyc-C） and urinary retinol binding protein （RBP） in early diabetic nephropathy patients.Methods A total of 26 cases of diabetic normal albuminuric period（DM）, 22 cases of early stage of diabetic nephropathy（DN）, 28 cases of diabetic nephropathy stage （DKD） and 23 cases in normal control group （NC） were selected.The levels of Myo, RBP, blood and urine Cyc-C were detected.At the same time, the levels of serum creatinine （CRE） and urinary albumin （mALB） were detedced, and the results were statistically analyzed.Results There was no significant difference between DM group and NC group （P〉0.05）.There were significant differences between NC group and DKD group, DN group （P〈0.01）.The positive rates of combined detection of serum Cyc-C, Myo and urine RBP, Cyc-C were higher than that of single index detection, the differences were significant（P〈0.05）.Conclusions The combined detection of serum myoglobin （myo）, urinary cystatin C Cyc-C and urinary retinol protein （RBP） has important significance in the early diagnosis of diabetic nephropathy.

关 键 词：早期糖尿病肾病 血清肌红蛋白 尿胱抑素C 尿视黄醇结合蛋白 

分 类 号：R587.2[医药卫生—内分泌] R692.9[医药卫生—内科学]