鼻咽癌MRI三维径线和体积测量及与临床分期的相关性  

Three-dimentional measurement of thicknesss and volume of nasopharyngeal carcinoma based on preoperative MRI and correlation with clinical stage

作　　者：马高[1] 许晓泉[1] 胡昊[1] 洪汛宁[1] 吴飞云[1] 施海彬[1] 孙新臣[2] 

机构地区：[1]南京医科大学第一附属医院放射科,南京210029 [2]南京医科大学第一附属医院放疗科,南京210029

出　　处：《放射学实践》2017年第8期827-830,共4页Radiologic Practice

摘　　要：目的:探讨鼻咽癌MRI三维径线和体积(PTV)测量及与临床分期的相关性。方法:回顾性分析经病理证实的118例鼻咽癌患者的临床及影像学资料。基于横轴面、冠状面和矢状面脂肪抑制T_2WI,分别测量鼻咽癌病灶的左右径(MLD)、上下径(CCD)和前后径(APD),并采用面积求和法计算PTV。结果:进展期肿瘤(T3+T4期)组的PTV、APD、MLD和CCD均明显高于非进展期肿瘤(T1+T2期)组(P<0.05)。PTV、APD、MLD和CCD在N0期和非N0期(N1+N2+N3)组间的差异均无统计学意义(P>0.05)。受试者工作特性(ROC)曲线分析结果显示,APD和CCD鉴别进展性和非进展期肿瘤的诊断效能与PTV相似(P>0.05),而MLD明显低于PTV(P<0.05)。结论:鼻咽癌MRI三维径线和体积测量值与其T分期密切相关。Objective：To evaluate the significance of three-dimensional measurement of the tumor thickness and tumor volume based on preoperative MRI and the correlation with clinical stage in patients with nasopharyngeal carcinoma （NPC）. Methods：Clinical and imaging data of 118 patients with pathologically proven NPC were retrospectively analyzed. Tumor thickness was measured on axial （medial-lateral diameter, MLD）, coronal （cranio-caudal diameter, CCD） and sagittal （anterior-posterior diameter,APD） fat-suppressed T2-weighted images,and tumor volume was calculated using area summation method. Results： APD, MLD,CCD and tumor volume in advanced （T3 ＋T4 stage） group were significantly higher than those in non-advanced （T1 ＋ T2 stage） group （P〈 0.05）. There was no statistically significant difference in APD, MLD,CCD and tumor volume between NO and non-N0 （NI＋N2q-N3） group （P〉0.05）. Receiver operating characteristic （ROC） curve analysis indicated that APD and CCD showed comparable performance in differentiating advanced from non- advanced group when compared with tumor volume （P〈0.05）, while MLD showed significantly lower differential value （P〈0.05）. Conclusion： Tumor thickness and tumor volume obtained by quantitative MRI measurement correlate signifi- cantly with the T stage.

关 键 词：鼻咽癌 磁共振成像 三维测量 肿瘤体积 临床分期 

分 类 号：R445.2[医药卫生—影像医学与核医学] R739.6[医药卫生—诊断学]