转化生长因子-β1及其介导的信号通路在百草枯致肺上皮间质转化中的作用  

Roles of transforming growth factor-beta 1 and its mediated signaling pathways in pulmonary epithelial mesenchymal transition induced by paraquat

作　　者：姜岩[1] 于功昌[2] 张兴国[3] 

机构地区：[1]济南大学山东省医学科学院医学与生命科学学院,山东济南250062 [2]山东省医学科学院山东省职业卫生与职业病防治研究院,山东济南250062 [3]山东大学附属省立医院中毒与职业病科,山东济南250021

出　　处：《环境与职业医学》2017年第8期729-733,共5页Journal of Environmental and Occupational Medicine

基　　金：山东省中医药科技发展计划(编号:2015-328);山东省自然科学基金(编号:ZR2015YL046)

摘　　要：近年来,除草剂在农业生产中广泛使用,中毒事件时有发生,其中以百草枯中毒多见,死亡率较高。百草枯中毒的主要靶器官是肺脏,其病理改变主要为早期的肺泡炎、肺水肿及晚期的肺纤维化。百草枯中毒致肺纤维化的机制复杂,新近研究发现多种细胞因子及其介导的信号通路是百草枯致肺纤维化形成过程中的关键环节。本文对转化生长因子-β1(TGF-β1)及其介导的主要细胞信号通路(Smads、MAPK、Wnt)在百草枯致肺上皮间质转化中的作用进行综述。In recent years, with the wide application of herbicides in agricultural production, pesticide poisoning events which are mainly caused by paraquat occur frequently and lead to a high mortality rate. Lung is the main target organ of paraquat poisoning, and its pathological changes include early alveolitis, pulmonary edema, and advanced pulmonary fibrosis. The pulmonary fibrosis mechanism of paraquat poisoning is complex. Recent studies show that a variety of cytokines and signaling pathways are key to the formation of pulmonary fibrosis. In this paper, we reviewed the roles of transforming growth factor-beta 1 （TGF-β1） and its mediated cell signaling pathways （Smads, MAPK, and Wnt） in pulmonary epithelial mesenchymal transition induced by paraquat.

关 键 词：百草枯 肺纤维化 转化生长因子-Β1 上皮间质转化 信号通路 

分 类 号：R139.3[医药卫生—劳动卫生]