盐霉素诱导细胞自噬机制的抗肿瘤应用进展  

Application Progress of Antitumor Mechanism of Autophagy-induced Salinomycin

作　　者：方宇鹏[1] 王毅[1] 

机构地区：[1]南华大学附属第二医院,湖南衡阳421001

出　　处：《世界最新医学信息文摘》2017年第19期29-29,31,共2页World Latest Medicine Information Electronic Version

摘　　要：在肿瘤的产生、发展以及治疗的整个过程中,自噬都具有重要的作用。而盐霉素是一种离子载体型的聚醚类抗生素,在鸡球虫病治疗以及反刍动物生长促进中一直有所应用。盐霉素能够将耐药多药肿瘤细胞系以及多种肿瘤干细胞杀死,其中就产生了自噬效应。盐霉素诱导细胞自噬具有一定的复杂性,其能增加细胞内的活性氧,使得自噬被激活,还能利用线粒体损伤诱导其自身自噬;还能导致内质网产生应激反应,并通过激活AKT-m TOR信号通路将自噬效应激活。另外盐霉素还能对晚期阶段的自噬潮进行抑制,以利于提高抗肿瘤作用以及破坏肿瘤微环境。因此本文对盐霉素诱导细胞自噬机制的抗肿瘤应用进展做了详细的阐述。autophagy has been playing an important part during generation,development and treatment of tumors.As polyether antibiotic of ion carrier type,salinomycin has been applied in treatment of chicken coccidiosis and promotion of growth of ruminant animals.It can kill multidrug resistant tumor-cell lines and a variety of tumor stem-cells,in which autophagy effect occurs.Autophagy induction of salinomycin has some certain complexity,it can increase active oxygen in cells to activate autophagy,and induce self autophagy of mitochondrion through its damage,and lead to stress reaction of endoplasmic reticulum,and activate self autophagy effect through activating signaling pathway of AKT-m TOR.In addition,salinomycin can inhibit autophagy flux at late stage,which is helpful to improve anti-tumor effect and destroy tumor microenvironment.Therefore,the article related progress of anti-tumor application of salinomycin induced cell autophagy mechanism in details.

关 键 词：盐霉素 细胞自噬机制 诱导 抗肿瘤 应用进展 

分 类 号：R246.5[医药卫生—针灸推拿学]