百丹疏肝方治疗抗肺结核合并真菌感染药物所致肝损伤196例疗效观察  

Effect Observation of 196 Cases of Liver Injury Due to Anti-Tuberculosis and Fungal Infection Treated by Baidan Shugan Formula

作　　者：路振宇[1] 党殿杰 王京[2] 杨红亮[3] 李军[1] 朱孝轩[4] 刁淑梅 张丹[1] 张丁[1] 郭玲玲[1] 

机构地区：[1]河北省邯郸市传染病医院,河北邯郸056002 [2]河北工程大学科信学院,河北邯郸056038 [3]冀中能源峰峰集团有限公司总医院,河北邯郸056002 [4]河北工程大学附属医院,河北邯郸056002

出　　处：《山东中医杂志》2017年第8期647-649,653,共4页Shandong Journal of Traditional Chinese Medicine

基　　金：河北省邯郸市科学技术研究与发展计划项目(编号:1623208022ZC)

摘　　要：目的 :探讨百丹疏肝方对抗肺结核合并真菌感染药物所致肝损伤的临床疗效。方法 :将196例患者随机分为两组,每组98例,对照组口服甘草酸二铵肠溶胶囊治疗,试验组服用自拟百丹疏肝方,疗程4周结束后对比分析两组患者的临床疗效。结果:试验组显效率、总有效率均优于对照组(P<0.05);两组丙氨酸氨基转移酶(ALT)、门冬氨酸氨基转移酶(AST)、总胆红素(TBil)水平均明显降低(P<0.05),试验组在降低ALT、AST、Tbil水平方面优于对照组(P<0.05);试验组发热、消化道症状、乏力、肝区不适消失时间短于对照组(P<0.05);试验组4周内恢复抗结核、抗真菌治疗情况明显好于对照组(P<0.05);试验组对原发病控制情况好于对照组(P<0.05)。结论:百丹疏肝方治疗抗肺结核合并真菌感染药物所致肝损伤临床效果显著,为进一步的抗结核、抗真菌治疗打下基础。Objective：To explore the clinical effect of Baidan Shugan formula for liver injure due to anti-tuberculosis and fungal infection. Methods：There were 196 patients randomly divided into two groups,98 cases in each group. In the control group,patients were given diammonium glycyrrhizinate enteric-coated capsules orally and in the experimental group,patients were given Baidan Shugan formula. After 4 weeks,the clinical effect was compared between the two groups. Results：The effectiveness and total effectiveness in the experi- mental group were better than those in the control group（P〈0.05）. In both groups,the levels of ALT, AST,TBil level decreased significantly （P〈 0.05 ） , and the decrease in the experimental group was more obviously than that in the control group（P〈0.05）. The time for disappearing of fever,gastrointestinal symptoms,fatigue,discomfort in liver area was less than that in the control group（P〈0.05）. In experimental group, patients were given anti-tuberculosis antifungal treatment after no more than 4 weeks,and the condition was better than that in the control group（P〈0.05）. The control of the primary disease in the experimental group was better than that in the the control group（P〈0.05）. Conclusion：Baidan Shugan formula showed satisfactory effect for liver injury due to anti-tuberculosis complicated and fungal infection,and therefore it is a basis for further treating tuberculosis and fungal infection.

关 键 词：百丹疏肝方 药物性肝损伤 肺结核合并真菌感染 保肝 

分 类 号：R259.752.9[医药卫生—中西医结合] R978.3[医药卫生—中医内科学]