肝移植术后完全停用免疫抑制剂三例儿童临床特点分析  

Clinical characteristics of complete immunosuppression withdrawal in pediatric recipients： a report of 3 cases

作　　者：宁禹[1] 张明满[1] 郭春宝[1] 唐艳[1] 吴娟[1] 

机构地区：[1]重庆医科大学附属儿童医院肝胆外科、儿童发育疾病研究教育部重点实验室、儿童发育重大疾病国家国际科技合作基地、儿科学重庆市重点实验室,400014

出　　处：《中华小儿外科杂志》2017年第8期572-574,共3页Chinese Journal of Pediatric Surgery

基　　金：国家临床重点专科建设项目（国卫办医函[2013]544）;重庆市科技计划项目（cstc2014yykfA110014）

摘　　要：目的探讨肝移植术后完全停用免疫抑制剂儿童的临床特征，寻找可能与术后免疫耐受形成有关的因素。方法回顾性分析我院2008年7月至2009年6月间完成的儿童肝移植中完全停用免疫抑制剂的3例患儿资料，包括：移植年龄、原发疾病、供肝来源、术后免疫抑制剂、随访检查结果等。结果3例完全停药儿童的原发病均为胆道闭锁，平均移植年龄7个月17d，均为母体活体供肝肝移植，肝移植术后免疫抑制剂方案均为强的松龙＋环孢素A，服药至少2年以上，完全停药1年以上。结论移植年龄〈1岁、原发病为胆道闭锁、母体供肝、服药2年以上、服用环孢素A是这些完全停药儿童的共同特征。Objective To explore the clinical characteristics of complete irnmunosuppression withdrawal in pediatric recipients and identify potential factors associated with immune toleranc〈 Methods The clinical data from 3 children undergoing liver transplamation between July 2008 and June 2009 at Children＇s Hospital were retrospectively analyzed, including age of donor/recipient at transplantation, transplant mode, primary disease and examination results. Results All primary diseases were biliary atresia and all cases of liver transplamation belonged to maternal living donor liver transplantation （LDLT）. Primary immunosuppressant was eyelosporine A. And all patients had completely withdrawn medications for at least 1 year. Condusions Age under 1 year,primary disease of hiliary atresia,maternal LDLT,dosing for at least 2 years and primary drug of cyclosporine A are the common clinical characteristics among these patients.

关 键 词：肝移植 免疫耐受 儿童 

分 类 号：R726.5[医药卫生—儿科]