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机构地区:[1]解放军白求恩国际和平医院营养科,石家庄050082 [2]解放军白求恩国际和平医院泌尿外科,石家庄050082 [3]天津医科大学第二医院营养科,天津300211
出 处:《解放军医药杂志》2017年第8期48-50,共3页Medical & Pharmaceutical Journal of Chinese People’s Liberation Army
基 金:河北省卫计委重点科技研究计划(20150387)
摘 要:目的评价低蛋白饮食对糖尿病肾病的治疗效果。方法选取2015年3月—2017年1月解放军白求恩国际和平医院收治的糖尿病肾病64例,随机分为研究组及对照组,每组32例。2组均进行常规饮食指导,研究组在此基础上给予优质低蛋白饮食,治疗周期为3个月。观察并比较2组治疗前后体重指数(BMI)、平均动脉压(MAP)、血红蛋白(Hb)、白蛋白(ALB)、尿素(BUN)、肌酐(Cr)、尿酸、肾小球滤过率(GFR)、24 h尿白蛋白、糖化血红蛋白(Hb A1c)、空腹血糖(FPG)、餐后2 h血糖(2 h PG)、血清甘油三酯(TG)、血清总胆固醇(TC)水平。结果研究组BMI、MAP、Hb、ALB、BUN、Cr、尿酸、GFR、24 h尿白蛋白、Hb A1c、FPG、2 h PG、TG、TC均优于治疗前及对照组(P<0.05)。结论优质低蛋白饮食可改善GFR,减轻肾小球硬化,提高血清ALB水平,延缓肾功能损伤。Objective To evaluate effect of low protein diet in treatment of patients with diabetic nephropathy. Methods A total of 64 patients with diabetic nephropathy during March 2015 and January 2017 were randomly divided into research group and control group (n = 32 for each group). All patients received regular diet guidance, and then research group was given a low-protein diet for 3 months. Body mass index (BMI) , mean arterial pressure (MAP) , hemoglobin (Hb), albumin (ALB), blood urea nitrogen (BUN), creatinine (Cr), uric acid, glomerular filtration rate (GFR), 24 h urinary albumin and glycated hemoglobin (HbA1c) , fasting plasma glucose (FPG), 2 h postprandial blood glucose (2 h PG) , serum triglyceride (TG) and serum total cholesterol (TC) levels were observed and compared before and after treatment in two groups. Results BMI, MAP, Hb, ALB, BUN, Cr, uric acid, GFR, 24 h urinary albumin, HbA1c, FPG, 2 h PG, TG and TC in research group were superior to those before treatment and in control group (P 〈 0.05). Conclusion High quality low-protein diet can improve GFR, alleviate glomerular sclerosis, improve serum ALB level and delay renal function injury of patients with diabetic nephropathy.
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