一种犬不稳定膀胱模型方法探讨及尿动力学评价  

Discussion about a kind of canine model of unstable bladder and changes of Urodynamics

作　　者：吴越[1] 张国飞[1] 邓玮[1] 陈安龙[1] 史京[1] 张旭[1] 李磊[1] 李飞[1] 

机构地区：[1]新疆医科大学第六附属医院泌尿外科,乌鲁木齐830002

出　　处：《新疆医学》2017年第7期695-697,共3页Xinjiang Medical Journal

基　　金：新疆维吾尔自治区自然科学基金(2014211C133)

摘　　要：目的探讨建立雌犬逼尿肌不稳定膀胱(DI)动物模型的方法,并观察其尿流动力学变化状况。方法 8只比格犬行全麻下行经尿道外口尿道环扎术。术后3个月、6个月分别行尿动力学检测。结果建模所需手术时间13~22 min,平均(15.7±3.9)min。术前尿动力检测:最大逼尿肌压力(MDP)(34.729±2.7699)、最大膀胱容量(MCC)(91.286±7.6095)、膀胱最大顺应性(MBC)(4.067±0.6038);术后3月尿动力检测:最大逼尿肌压力(MDP)(36.700±3.6815)、最大膀胱容量(MCC)(100.143±9.2453)、膀胱最大顺应性(MBC)(3.319±0.6257)。MBC术前术后有统计学意义。结论经尿道外口途径建立雌犬逼尿肌不稳定膀胱模型方法简便,创伤小,可为今后开展经尿道治疗OAB提供一种途径。Objective To establish a kind of detrusor instability(DI)bladder model for female dogs and test changes of urodynamics.Methods 8 beagle dogs were treated with urethra cerclage through external urethral orifice under general anesthesia. Urodynamic test was performed at 3 and 6 months after surgery. Results The time required for the establishment of the animal model was about 13~22min,and average time was about(15.7±3.9)min. Urodynamic data before surgery showed the maximum detrusor pressure(MDP)was(34.729±2.7699),maximum bladder capacity(MCC)was(91.286±7.6095),maximum bladder compliance(MBC)was(4.067±0.6038);Urodynamic test data at 3 months after surgery showed the maximum detrusor pressure(MDP)was(36.700±3.6815),and maximum bladder capacity(MCC)was(100.143±9.2453),and maximum bladder compliance(MBC)was(3.319±0.6257). The maximal compliance(MBC)was statistically significantly different before and after operation. Conclusion There are some advantages about detrusor instability bladder model in female dogs such as simple operation and small trauma,and this model can provide a solution for the treatment of overactive bladder in the future.

关 键 词：犬 膀胱模型 逼尿肌不稳定 尿动力 

分 类 号：R639[医药卫生—外科学]