糖尿病肾病“肾痿”学说的建立与阐释  

Establishment and Explanation of“Consumptive Kidney Disease”Theory

作　　者：苗永辉[1] 赵宗江[1] 张新雪[1] 吴阿敏[1] 

机构地区：[1]北京中医药大学中医学院,北京100029

出　　处：《世界科学技术-中医药现代化》2017年第6期1031-1037,共7页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家自然科学基金委面上项目(81373831):基于"肾痿"组方的糖肾平干预糖尿病肾病肾小管上皮细胞转分化的分子机制研究;负责人:赵宗江

摘　　要：糖尿病肾病(Diabetic Kidney Disease,DKD)是糖尿病(Diabetes Mellitus,DM)严重的远期并发症和DM患者主要死因之一,严重威胁着人类健康。赵宗江教授首次提出了糖尿病肾病"肾痿"学说,并领导科研团队长期致力于"肾痿"学说指导下的糖尿病肾病研究,取得了一定的成果,归纳起来讲,主要在整体动物实验和体外细胞实验两个方面,从药效学、氧化应激水平和信号转导通路等角度进行深入研究。围绕着减少细胞外基质在肾小球系膜区以及肾小管间质的沉积、抑制足细胞损伤、抑制足细胞凋亡、抑制和逆转足细胞转分化、抑制肾小管上皮细胞转分化等科学问题,系统地阐明了糖尿病肾病"肾痿"学说的科学内涵。本文主要对"肾痿"学说的提出和相关的研究成果进行归纳整理与总结,以期补充"脏痿"学说和发展中医理论。Diabetic kidney disease （DKD） is a serious long-term complication and major death cause of patients who have suffered from diabetes mellitus （DM）, which is a serious threat to the health of human being. Professor Zhao Zongjiang first came up with the of DKD ＂consumptive kidney disease＂ scientific theory, and led the scientific research team for DKD research. Our team had achieved some results, which were mainly focused on the animal experiments and cell culture experiment. And the research fields covered pharmacodynamics, oxidative stress levels and signal transduction pathways. Focusing on the reduction of extracellular matrix in the glomerular mesangial area and tubulointerstitial deposition, inhibition of podocyte injury, inhibition of podocyte apoptosis, inhibition and reversal of podocyte transdifferentiation, inhibition of renal tubular epithelial cell transdifferentiation and other scientific issues, this paper systematically explored the biological mechanism of DKD ＂consumptive kidney disease＂ scientific theory. This paper explained how ＂consumptive kidney disease＂ scientific theory was proposed and summarized related research results of our research team and developed traditional Chinese medicine （TCM） theory by supplying the TCM ＂consumptive organ disease＂ theory.

关 键 词：糖尿病肾病 慢性肾脏疾病 “肾痿”学说 中医理论 

分 类 号：R285.5[医药卫生—中药学]