化橘红的研究进展  

Research Progress of Citri Grandis Exocarpium

作　　者：王艳慧 

机构地区：[1]广州市香雪制药股份有限公司,广州510663

出　　处：《世界科学技术-中医药现代化》2017年第6期1076-1082,共7页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：广东省科技厅科技基础条件建设领域项目(2015B030301005);广东省天然产物标准物质分离企业重点实验室建设项目;负责人:连林生

摘　　要：目的:对近年来国内外化橘红的研究进展进行综述,充分挖掘其药用价值,以期为更好的利用和开发化橘红提供参考依据。方法:利用中国知网、万方数据库、维普和Pubmed等进行文献检索,从本草学研究、化学成分、药理作用、临床研究等方面总结和归纳化橘红的研究进展,并收集总结了近年来以化橘红为君药的药品的临床研究情况,为化橘红的临床应用及相关产品的开发利用提供进一步参考。结果:橘红与化橘红两种中药均为《中华人民共和国药典》收载品种,乾隆30年赵学敏《本草纲目拾遗》中,化橘红已正式立目单独分出,其后的本草著作多以此为基础,与历史上的橘皮橘红相区别。化橘红含有多糖、黄酮、香豆素、挥发油等成分,动物实验证明其具有显著的化痰止咳,抗炎、抗氧化、免疫调节、防治糖尿病心肌功能损伤等作用。既往的临床观察显示,化橘红具有止咳、祛痰和平喘的作用。结论:化橘红富含多糖、黄酮、香豆素、挥发油等多种活性成分,止咳、祛痰和平喘的效果好,药用价值高,值得进一步开发和利用。Recent advances in studies on Citri Grandis Exocarpium of both at home and abroad were reviewed, to fully dig its medicinal value, so as to provide reference for better utilization and development of Cirri Grandis Exocarpium. Literatures were retrieved from the China National Knowledge Infrastructure （CNKI）, Wanfang database, VIP database, PubMed and etc. Study progress was summarized and concluded from aspects of herbal medicine research, chemical constituents, pharmacological effects and clinical research. Clinical studies on Citri Grandis Exocarpium as the monarch drug in a prescription of recent years were collected and summarized, which provided further reference in the development and utilization of clinical application and its related products. The results showed that both Cirri Exocarpium Rubrum and Citri Grandis Exocarpium were herbal medicine recorded in the Pharmacopoeia of the People＇s Republic of China. In Qianlong 30 years, A Supplement to the Compendium of Materia Medica written by Zhao Xuemin, Citri Grandis Exocarpium has been officially made separately and then many later herbal works was based on this. Thus, Cirri Grandis Exocarpium was distinguished from Citri Exocarpium Rubrum which was throughout recorded history. Citri Grandis Exocarpium contained polysaccharides, flavonoids, coumarins, volatile oil, and etc. The animal experiments showed that it had significant effects on expectorant and antitussive, anti-inflammatory, antioxidation, immune regulation, prevention and treatment of diabetic myocardial injury. Clinical observations of the past also showed that Citri Grandis Exocarpium had antitussive, expectorant and antiasthmatic effect. It was concluded that Citri Grandis Exocarpium was rich in polysaccharides, flavonoids, coumarin, volatile oil and other active ingredients. It has good effect to treat cough, expectorant and asthma. Its medicinal value is high. It is worth of further development and utilization.

关 键 词：化橘红 研究进展 本草学研究 化学成分 药理作用 临床研究 

分 类 号：R282[医药卫生—中药学]